{"id":"W2108317489","doi":"10.1017/s1355838202024056","title":"High-affinity hnRNP A1 binding sites and duplex-forming inverted repeats have similar effects on 5??? splice site selection in support of a common looping out and repression mechanism","year":2002,"lang":"en","type":"article","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Université de Sherbrooke","keywords":"splice; Binding site; Biology; Splice site mutation; RNA splicing; snRNP; Alternative splicing; Genetics; RNA; Molecular biology; Gene; Exon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002935918,0.0001385497,0.0002065413,0.0001295942,0.0001104809,0.00002047856,0.00006171651,0.0001480612,0.000007690994],"category_scores_gemma":[0.0001981727,0.0001309801,0.00003140184,0.00008799342,0.00002927636,0.00001411287,0.0001210238,0.000163186,0.000002350366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002261789,"about_ca_system_score_gemma":0.00001014367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001899535,"about_ca_topic_score_gemma":0.0003608472,"domain_scores_codex":[0.9989613,0.00009273875,0.0002046453,0.0003443197,0.000143784,0.0002532473],"domain_scores_gemma":[0.999551,0.00005861494,0.00009962264,0.0001647548,0.0000343899,0.00009162313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008486744,0.00004500712,0.01121504,0.0001213181,0.00001700115,0.00001641607,0.000176554,0.00003675181,0.9846587,0.0000158168,0.0001798077,0.003432742],"study_design_scores_gemma":[0.0007307194,0.0006496191,0.003551318,0.0001606906,0.00001110036,0.00001585031,0.00003888948,0.01056895,0.9840149,0.00004879727,0.00006459458,0.0001445836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992473,0.0001840646,0.00009676162,0.0000853616,0.00002533494,0.0002143265,0.000005535486,0.00001166526,0.0001296807],"genre_scores_gemma":[0.9986597,0.0005052696,0.0002912403,0.0001300809,0.00004858971,0.000009046788,0.00003244426,0.00001623117,0.0003074069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0105322,"threshold_uncertainty_score":0.5341213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072259149434399,"score_gpt":0.2710413167389171,"score_spread":0.2503187252445731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}