{"id":"W2108319997","doi":"10.1128/aac.01661-08","title":"Safety and Pharmacokinetics of Chimeric Anti-Shiga Toxin 1 and Anti-Shiga Toxin 2 Monoclonal Antibodies in Healthy Volunteers","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"Pharmacokinetics; Shiga toxin; Medicine; Antibody; Adverse effect; Monoclonal antibody; Toxin; Internal medicine; Gastroenterology; Pharmacology; Immunology; Microbiology; Escherichia coli; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002068617,0.0002834484,0.0004413063,0.00009345719,0.0001280657,0.00003755705,0.0001375109,0.0001334982,0.00001370206],"category_scores_gemma":[0.0000207602,0.000264469,0.00005765455,0.0001659651,0.0003234669,0.00001487182,0.0001202434,0.0001572855,4.747176e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001085135,"about_ca_system_score_gemma":0.00004575618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008818878,"about_ca_topic_score_gemma":0.00003413837,"domain_scores_codex":[0.9985279,0.00006688457,0.0003575647,0.0004888031,0.0001375911,0.0004211921],"domain_scores_gemma":[0.9995207,0.00001627368,0.0001066516,0.000177861,0.00006101485,0.0001175411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007696923,0.0002757135,0.1333039,0.0001072285,0.0001352125,0.000007666035,0.0003755311,0.00001805901,0.8517736,0.00002224513,0.003105909,0.01010528],"study_design_scores_gemma":[0.005148368,0.0009059621,0.8293761,0.00009390812,0.00002926064,0.00003213336,0.0001311571,0.0004106425,0.1434598,0.00002537439,0.01987606,0.0005112528],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945031,0.001735916,0.00005193632,0.00310907,0.00005643066,0.0003191606,0.00004924219,0.00001027771,0.0001648783],"genre_scores_gemma":[0.9203109,0.07430342,0.0008664184,0.004265937,0.00008847193,0.000002411163,0.00003177323,0.00002265083,0.0001080156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7083138,"threshold_uncertainty_score":0.9999807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155680368626127,"score_gpt":0.290652616142705,"score_spread":0.2790958124564437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}