{"id":"W2108319997","doi":"10.1128/aac.01661-08","title":"Safety and Pharmacokinetics of Chimeric Anti-Shiga Toxin 1 and Anti-Shiga Toxin 2 Monoclonal Antibodies in Healthy Volunteers","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"Pharmacokinetics; Shiga toxin; Medicine; Antibody; Adverse effect; Monoclonal antibody; Toxin; Internal medicine; Gastroenterology; Pharmacology; Immunology; Microbiology; Escherichia coli; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001152874,0.0005756708,0.0007624472,0.0001930887,0.0002677186,0.0003763284,0.0002217823,0.0007914172,0.0007428384],"category_scores_gemma":[0.001854469,0.0004195509,0.0002930561,0.0001485325,0.0005677365,0.0004207832,0.0001798542,0.0007421757,0.0004499753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002482268,"about_ca_system_score_gemma":0.0003006358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004268511,"about_ca_topic_score_gemma":0.0002820306,"domain_scores_codex":[0.9993106,0.0003702772,0.0000298742,0.000146924,0.00008497966,0.00005735696],"domain_scores_gemma":[0.9991972,0.0001964012,0.0001675285,0.00009079061,0.00009853001,0.000249687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4230149,0.02249848,0.04700373,0.0003830635,0.0005183388,0.001171117,0.001037217,0.001912341,0.4045607,0.0002322291,0.001676992,0.09599086],"study_design_scores_gemma":[0.02359048,0.758016,0.1680267,0.00004349474,0.0005495601,0.001834766,0.0002808729,0.005236546,0.03796441,0.0003509853,0.00402504,0.00008127965],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979772,0.0006803632,0.0005449536,0.00004136092,0.00001859167,0.0001506116,0.0001188274,0.0000342085,0.000434004],"genre_scores_gemma":[0.9981689,0.0002446882,0.0004571454,0.0001598979,0.00005458232,0.0001840468,0.0002501201,0.00001105525,0.0004694226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152874,"threshold_uncertainty_score":0.006097019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155680368626127,"score_gpt":0.290652616142705,"score_spread":0.2790958124564437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}