{"id":"W2108336316","doi":"10.1016/j.humimm.2011.12.002","title":"Human leukocyte antigen (HLA) and pharmacogenetics: screening for HLA-B*57:01 among human immunodeficiency virus–positive patients from southern Alberta","year":2011,"lang":"en","type":"article","venue":"Human Immunology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health Services; Alberta Hip and Knee Clinic; University of Calgary; Calgary Laboratory Services","funders":"Ministry of Economy, Trade and Industry","keywords":"Abacavir; Genotyping; Human leukocyte antigen; HLA-B; Immunology; Medicine; HLA-B Antigens; Odds ratio; Pharmacogenetics; Virology; Genotype; Internal medicine; Antigen; Biology; Viral load; Human immunodeficiency virus (HIV); Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003632965,0.00039785,0.0002375386,0.0006553964,0.001300876,0.0006233616,0.0005068673,0.000312482,0.001223594],"category_scores_gemma":[0.0009075834,0.0002427257,0.0001891647,0.001019742,0.0004486585,0.0001414116,0.0003376981,0.0004354297,0.000112353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002793347,"about_ca_system_score_gemma":0.002831833,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7527767,"about_ca_topic_score_gemma":0.7520568,"domain_scores_codex":[0.9996018,0.00007239753,0.00003029062,0.000064148,0.0001381445,0.00009335118],"domain_scores_gemma":[0.999587,0.00007262051,0.00006268523,0.00001755199,0.0001105426,0.0001496164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001451127,0.00006423676,0.9925588,0.000009669145,0.00002599856,0.001731896,0.0009706757,0.0000924214,0.001465579,0.00004119972,0.0002110231,0.002683425],"study_design_scores_gemma":[0.00001850554,0.0001077192,0.995987,0.000009202534,0.00003940296,0.001201868,0.001866701,0.0001772253,0.0001783471,0.00001979699,0.0003890783,0.000005071867],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986921,0.00009291297,0.00004330702,0.0000636382,0.000003957651,0.00000855759,0.00007468096,0.000001881306,0.00101902],"genre_scores_gemma":[0.9993956,0.0000782112,0.00005010111,0.00006644983,0.000003260597,0.000001963082,0.00005237813,0.000001481631,0.0003505959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2472233,"threshold_uncertainty_score":0.4973584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04751553858669348,"score_gpt":0.2946621957993025,"score_spread":0.247146657212609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}