{"id":"W2108344711","doi":"10.3389/fchem.2014.00012","title":"Activation of GATA4 gene expression at the early stage of cardiac specification","year":2014,"lang":"en","type":"article","venue":"Frontiers in Chemistry","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Histone deacetylase; GATA4; Histone; Induced pluripotent stem cell; Coactivator; Histone acetyltransferase; Acetylation; Cell biology; Biology; Histone deacetylase inhibitor; Regulation of gene expression; Gene expression; HDAC11; HDAC4; Cancer research; Cellular differentiation; Stem cell; Gene; Embryonic stem cell; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275899,0.00007499311,0.0001209133,0.00001838229,0.0000276447,0.000004393981,0.0001657263,0.0001142875,0.00002860575],"category_scores_gemma":[0.0001208061,0.00006370583,0.00006215131,0.0000850815,0.0001099923,0.000003647278,0.0001173083,0.00008147985,0.000001134009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003193095,"about_ca_system_score_gemma":0.00003104257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002203018,"about_ca_topic_score_gemma":0.000001716485,"domain_scores_codex":[0.999275,0.00005406075,0.0001724012,0.0001958654,0.0001776631,0.0001249925],"domain_scores_gemma":[0.9993374,0.00001937856,0.00008830721,0.00045755,0.00006671336,0.00003067486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009736358,0.00002086618,0.02484983,0.00007684912,0.00001165823,6.932081e-8,0.00003407467,0.00001911418,0.9697607,9.306536e-7,0.001795354,0.003333239],"study_design_scores_gemma":[0.0001527,0.0000268967,0.01082752,0.00001558936,0.000002813262,2.836003e-7,0.0000645131,0.00005005905,0.97632,0.00001256062,0.01246682,0.00006026346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963645,0.000435783,0.001194511,0.00002136792,0.00006613479,0.0001240954,0.00003082672,0.000002544433,0.001760176],"genre_scores_gemma":[0.9949896,0.0001154026,0.0009126036,0.000003897798,0.00008367445,0.00001549667,0.0001051192,0.00001135848,0.003762837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0140223,"threshold_uncertainty_score":0.2597848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009590175555706813,"score_gpt":0.2490493038386299,"score_spread":0.2394591282829231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}