{"id":"W2108349823","doi":"10.1371/journal.pone.0049516","title":"Botulinum Neurotoxin Serotype a Specific Cell-Based Potency Assay to Replace the Mouse Bioassay","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan","keywords":"Bioassay; Potency; Pharmacology; Botulinum neurotoxin; Neurotoxin; Biology; Biochemistry; Toxin; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000535157,0.0002762183,0.000381529,0.0001019748,0.0001619083,0.00002878103,0.0002587486,0.0002603849,0.0007704733],"category_scores_gemma":[0.0003374232,0.0001726495,0.0001513748,0.0005270338,0.0001096937,0.00006647357,0.00008274859,0.0008266235,0.001902343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000375357,"about_ca_system_score_gemma":0.0000449466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001235802,"about_ca_topic_score_gemma":0.000002043109,"domain_scores_codex":[0.9976872,0.0002749066,0.0003491136,0.0004251558,0.0005830084,0.0006806394],"domain_scores_gemma":[0.998233,0.0002583406,0.00009296538,0.0008394254,0.00009024563,0.0004860818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00189068,0.01408248,0.0300157,0.0002343799,0.0002443084,0.0001096959,0.0004680055,0.0001119913,0.9211389,0.0001744292,0.03061006,0.0009194141],"study_design_scores_gemma":[0.007837635,0.004291603,0.04941301,0.0003205882,0.001058849,0.00005183865,0.0002741409,0.002178423,0.8481277,0.0001682724,0.08489286,0.00138504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480975,0.0008809606,0.0003257036,0.03415642,0.0001705875,0.002005315,0.00001362506,0.000347647,0.01400226],"genre_scores_gemma":[0.9745687,0.0002333058,0.001601146,0.0137401,0.000283057,0.0001014316,0.00001767275,0.00006917184,0.009385421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07301112,"threshold_uncertainty_score":0.9988748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05201044735315257,"score_gpt":0.2378747988555875,"score_spread":0.1858643515024349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}