{"id":"W2108383176","doi":"10.1158/0008-5472.can-05-3297","title":"Adeno-Associated Virus–Mediated Delivery of a Mutant Endostatin in Combination with Carboplatin Treatment Inhibits Orthotopic Growth of Ovarian Cancer and Improves Long-term Survival","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Cancer Institute; University of Minnesota; National Institute on Drug Abuse; Minnesota Ovarian Cancer Alliance","keywords":"Carboplatin; Ovarian cancer; Endostatin; Cancer research; Genetic enhancement; Metastasis; Medicine; Cisplatin; Adeno-associated virus; Cancer; Sleeping Beauty transposon system; Biology; Pathology; Chemotherapy; Internal medicine; Mutant; Angiogenesis; Gene; Recombinant DNA; Vector (molecular biology); Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231593,0.0003457253,0.0004214299,0.0002737133,0.0001086083,0.0002378849,0.000170233,0.0002282843,0.0004868655],"category_scores_gemma":[0.00007478252,0.0001486537,0.0002349176,0.0001654665,0.0001792011,0.0001633345,0.0001365503,0.0004816385,0.0001233892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002870384,"about_ca_system_score_gemma":0.0002486382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140124,"about_ca_topic_score_gemma":0.002054367,"domain_scores_codex":[0.9998764,0.00001601736,0.00001256903,0.00002970022,0.00003369432,0.00003165204],"domain_scores_gemma":[0.9999294,0.00001113,0.00001873949,0.000009924917,0.000005169571,0.00002564051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001363399,0.0000969208,0.0001410731,0.00001905043,0.000006208544,0.00002200249,0.000011687,0.00007661826,0.9981658,0.00002909635,0.0000349048,0.001260322],"study_design_scores_gemma":[0.00005885205,0.001664397,0.005060998,0.000002981958,0.00003232127,0.0002685118,0.00001814513,0.001383387,0.9899179,0.00001601909,0.001570764,0.000005623245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974799,0.0009325892,0.0008548486,0.00004308261,0.00002289868,0.00002951963,0.00009187512,0.00005123716,0.0004940763],"genre_scores_gemma":[0.9967735,0.0005318081,0.001199408,0.00002062613,0.000006613913,0.00004226001,0.0002396015,0.0000129377,0.001173166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00140124,"threshold_uncertainty_score":0.00278616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448687007832923,"score_gpt":0.3244487853369105,"score_spread":0.2999619152585813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}