{"id":"W2108432057","doi":"10.1128/jvi.05835-11","title":"Modulation of NKG2D-Mediated Cytotoxic Functions of Natural Killer Cells by Viral Protein R from HIV-1 Primary Isolates","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Alberta; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Health Canada; Canadian Foundation for AIDS Research; National Institutes of Health; amfAR, The Foundation for AIDS Research","keywords":"Biology; NKG2D; Effector; Cytotoxic T cell; Ubiquitin ligase; Cell biology; Cell cycle checkpoint; DDB1; Viral replication; DNA damage; Cell cycle; Cell; Virology; Virus; Molecular biology; Ubiquitin; DNA; Gene; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008405205,0.0003059145,0.0002807108,0.0001028808,0.0001039314,0.0002510252,0.0001761507,0.0001636879,0.0009191722],"category_scores_gemma":[0.000153308,0.00008664346,0.0002277367,0.0000817351,0.0001802183,0.0001167666,0.0001988023,0.0003944401,0.000283285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002613854,"about_ca_system_score_gemma":0.000121781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003053489,"about_ca_topic_score_gemma":0.000457407,"domain_scores_codex":[0.9998441,0.00003247829,0.00001514817,0.00002992192,0.00002726912,0.00005110522],"domain_scores_gemma":[0.999929,0.00001751847,0.0000117913,0.00001492693,0.000008269079,0.00001854573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001534619,0.00002942829,0.000214593,0.00002631763,0.000004423145,0.00005403433,0.00001134679,0.00007758765,0.9980636,0.0000318325,0.00003162598,0.001301667],"study_design_scores_gemma":[0.00003012604,0.0007163424,0.006019003,0.000004390112,0.00001354095,0.0003895139,0.00002960715,0.0004654628,0.9912847,0.00003448188,0.001009444,0.000003336778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979062,0.000539634,0.0005202349,0.00002291942,0.00001208692,0.00002010913,0.0001203092,0.00002388745,0.0008345565],"genre_scores_gemma":[0.9976421,0.0004280515,0.0006903386,0.00003037458,0.000009173698,0.00002803109,0.0003711502,0.000008533946,0.0007922791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009191722,"threshold_uncertainty_score":0.003074884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007496585272041135,"score_gpt":0.1914884469699926,"score_spread":0.1839918616979515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}