{"id":"W2108434880","doi":"10.1371/journal.pgen.1002313","title":"Genetic Determinants of Serum Testosterone Concentrations in Men","year":2011,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Leibniz-Gemeinschaft; Canadian Institutes of Health Research; Leibniz-Rechenzentrum; Wake Forest University; Ministry of Cultural Affairs; National Institutes of Health; Bayerische Akademie der Wissenschaften; Göteborgs Universitet; Siemens; Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Novo Nordisk; Stiftelsen för Strategisk Forskning; Erasmus Medisch Centrum; Münchner Zentrum für Gesundheitswissenschaften; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Johns Hopkins University; Erasmus Universiteit Rotterdam; Novo Nordisk Fonden; School of Medicine, Boston University; European Commission; Universität Greifswald; ZonMw","keywords":"Sex hormone-binding globulin; Biology; Endocrinology; Internal medicine; Testosterone (patch); Single-nucleotide polymorphism; Allele; Locus (genetics); Androgen; Genetics; Genotype; Hormone; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005955371,0.0002623203,0.001488071,0.0001219406,0.00002479813,0.000002679499,0.0001200798,0.0001532561,0.00004021673],"category_scores_gemma":[0.00006430455,0.0001882786,0.0001503163,0.0001990657,0.0001576961,0.000009330545,0.00009891523,0.0001885343,0.00003716137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004409687,"about_ca_system_score_gemma":0.000228006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005671523,"about_ca_topic_score_gemma":0.00003140971,"domain_scores_codex":[0.9985519,0.00006046145,0.0006541362,0.0003392334,0.0001624811,0.0002317687],"domain_scores_gemma":[0.9991381,0.00004047178,0.000232993,0.0003982503,0.0001178332,0.00007236372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007565745,0.0004170026,0.0258865,0.01652615,0.0003172122,0.00004814298,0.0004787499,2.623207e-7,0.00004373254,0.000005578484,0.00004795933,0.9562212],"study_design_scores_gemma":[0.001794892,0.002182745,0.1026034,0.04454058,0.01020199,0.0002997496,0.0003220235,0.00008906535,0.003697259,0.000155255,0.8327301,0.001382975],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007047497,0.9899209,5.609735e-7,0.000007556035,0.00006738986,0.0009620769,0.00006295551,0.00001031904,0.001920766],"genre_scores_gemma":[0.006796237,0.9921333,0.0004009671,0.000006293164,0.0001660568,0.00006102489,0.000007273907,0.0000383328,0.0003905794],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9548382,"threshold_uncertainty_score":0.767778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1225364143440533,"score_gpt":0.3419339837824147,"score_spread":0.2193975694383615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}