{"id":"W2108446207","doi":"10.1371/journal.pgen.1000977","title":"An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits","year":2010,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; Jewish General Hospital; McGill University and Génome Québec Innovation Centre","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Uppsala Universitet; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Osteoporosis Canada; Erasmus Medisch Centrum; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; European Commission; Helsingin Yliopisto; Genome Canada; ZonMw; School of Medicine, Boston University","keywords":"Genome-wide association study; Biology; Candidate gene; Genetic association; Genetics; Osteoporosis; Quantitative trait locus; Femoral neck; Heritability; Gene expression profiling; Genome; SNP; Gene; Single-nucleotide polymorphism; Bioinformatics; Computational biology; Gene expression; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003209124,0.000768599,0.00163659,0.002114522,0.0004574349,0.001158479,0.0005677714,0.0007081405,0.00109967],"category_scores_gemma":[0.002486261,0.0003452808,0.001954577,0.003334458,0.0003015237,0.0003568112,0.000593006,0.0007595483,0.0002426054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003361382,"about_ca_system_score_gemma":0.001097241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002818568,"about_ca_topic_score_gemma":0.007574628,"domain_scores_codex":[0.9986472,0.0005025184,0.0001371128,0.0003437137,0.0002848578,0.00008457151],"domain_scores_gemma":[0.998886,0.000609297,0.0001734512,0.0001166699,0.0001364745,0.00007799239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003258326,0.0004300906,0.6324623,0.002841618,0.02241333,0.001830052,0.0002215476,0.002666146,0.1832095,0.001276999,0.003201255,0.1461889],"study_design_scores_gemma":[0.0009356753,0.00121473,0.9241684,0.0002948006,0.0225277,0.001903912,0.0002733842,0.008931261,0.0192902,0.003861745,0.01648946,0.0001088242],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.86328,0.08684396,0.03756102,0.003458193,0.0004581237,0.0003566751,0.004914321,0.0004533794,0.00267427],"genre_scores_gemma":[0.9291478,0.01703197,0.04695429,0.001552378,0.0004063074,0.0002820181,0.003106052,0.00007860166,0.001440741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003209124,"threshold_uncertainty_score":0.01697171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141227488648375,"score_gpt":0.2632830034569566,"score_spread":0.2491602545921191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}