{"id":"W2108446207","doi":"10.1371/journal.pgen.1000977","title":"An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits","year":2010,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; Jewish General Hospital; McGill University and Génome Québec Innovation Centre","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Uppsala Universitet; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Osteoporosis Canada; Erasmus Medisch Centrum; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; European Commission; Helsingin Yliopisto; Genome Canada; ZonMw; School of Medicine, Boston University","keywords":"Genome-wide association study; Biology; Candidate gene; Genetic association; Genetics; Osteoporosis; Quantitative trait locus; Femoral neck; Heritability; Gene expression profiling; Genome; SNP; Gene; Single-nucleotide polymorphism; Bioinformatics; Computational biology; Gene expression; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003126106,0.0001133053,0.0001691487,0.0000253558,0.00006114888,0.00002318821,0.000135176,0.0001182868,0.000001778543],"category_scores_gemma":[0.000508591,0.00008622508,0.00005354712,0.00006592298,0.00004363837,0.000008924966,0.00006167332,0.00006394587,1.105417e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006420213,"about_ca_system_score_gemma":0.00005895316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005126493,"about_ca_topic_score_gemma":0.00009743095,"domain_scores_codex":[0.9990736,0.0000581123,0.0003120555,0.000268776,0.0001601916,0.0001272467],"domain_scores_gemma":[0.9991524,0.00005449956,0.0001860995,0.000298277,0.0002513794,0.00005731552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009801286,0.0006260753,0.0724493,0.00002553391,0.0000295679,2.774589e-8,0.0004837771,0.00006402664,0.9258968,0.000006000722,0.000009746752,0.0003111147],"study_design_scores_gemma":[0.0006684395,0.0004522039,0.1531696,0.000005021326,0.00009478948,1.243885e-7,0.0005748481,0.0002129309,0.8446801,0.00003848038,0.00001591906,0.00008748134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963683,0.0002565963,0.001946795,0.0000324786,0.00006472905,0.001062817,0.0002555225,0.000005209421,0.00000748763],"genre_scores_gemma":[0.9941442,0.00002427288,0.005458537,0.00003645344,0.00008394034,0.00004992083,0.0001606824,0.00001582771,0.00002618043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08121668,"threshold_uncertainty_score":0.3516157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141227488648375,"score_gpt":0.2632830034569566,"score_spread":0.2491602545921191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}