{"id":"W2108493925","doi":"10.1074/jbc.m202362200","title":"Crystal Structures of Inhibitor Complexes Reveal an Alternate Binding Mode in Orotidine-5′-monophosphate Decarboxylase","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Chemistry; Alanine; Stereochemistry; Binding site; Ligand (biochemistry); Crystal structure; Enzyme; Crystallography; Amino acid; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002679243,0.0001570906,0.0003745019,0.00004578303,0.00003958346,0.00003036982,0.0002792111,0.0001646017,0.0005810825],"category_scores_gemma":[0.0001304045,0.0001053475,0.000098304,0.0001126695,0.0001115361,0.0001755239,0.00004221476,0.0002567936,0.000001923395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005120188,"about_ca_system_score_gemma":0.00001494215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001393345,"about_ca_topic_score_gemma":0.000002544744,"domain_scores_codex":[0.9986727,0.00005805802,0.0006341265,0.0001901803,0.0002190303,0.0002258605],"domain_scores_gemma":[0.9990911,0.0000533338,0.0005037683,0.0001339066,0.00009100774,0.0001268356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775794,0.00006615028,0.003991561,0.00002551123,0.000005872538,0.00004440525,0.00005923488,0.0002866933,0.9948865,0.00002657494,0.0001049046,0.000325083],"study_design_scores_gemma":[0.000582847,0.0003117204,0.003414849,0.00005157094,0.000008738954,0.0001588084,0.00006470461,0.0001461265,0.9934006,0.001693853,0.00004051423,0.0001256508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989553,0.000299924,0.00003447995,0.00003839119,0.0002028527,0.00004328851,0.00002715796,0.00001247247,0.0003861217],"genre_scores_gemma":[0.9981375,0.00005789236,0.001331321,0.00003620855,0.0004039883,7.170951e-7,0.000005003507,0.000006210889,0.00002117263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001667278,"threshold_uncertainty_score":0.6362445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025764323240374,"score_gpt":0.2643426583169247,"score_spread":0.234085015084521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}