{"id":"W2108503320","doi":"10.1016/j.bbamcr.2007.10.008","title":"Prion protein aggresomes are poly(A)+ ribonucleoprotein complexes that induce a PKR-mediated deficient cell stress response","year":2007,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Aggresome; Stress granule; Protein kinase R; RNA; Ribonucleoprotein; Protein biosynthesis; Protein aggregation; Molecular biology; Cell biology; Chemistry; Biology; Translation (biology); Protein kinase A; Phosphorylation; Biochemistry; Messenger RNA; Apoptosis; Autophagy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002708816,0.0006791251,0.0004939336,0.0005649146,0.0005417228,0.0003652284,0.001310907,0.0005778855,0.00005505466],"category_scores_gemma":[0.0004991313,0.0006706776,0.0004432821,0.0009975265,0.0005433671,0.00002826085,0.001219912,0.0009444547,0.0001150512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524255,"about_ca_system_score_gemma":0.0004978513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551555,"about_ca_topic_score_gemma":0.00002564572,"domain_scores_codex":[0.9929092,0.001496093,0.0006278025,0.001566736,0.001661274,0.001738898],"domain_scores_gemma":[0.9965381,0.0002060411,0.0004409889,0.00161823,0.0004634575,0.0007332042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003220543,0.0009085127,0.00003910478,0.0002163388,0.00007221637,0.0001643192,0.0001524285,0.000005741393,0.9924737,0.00003357379,0.0004670268,0.002246509],"study_design_scores_gemma":[0.001373497,0.0009190845,0.003027044,0.0002146559,0.00002894916,0.000005770195,0.000486737,0.00004939003,0.9880376,0.00006926648,0.005014714,0.0007733107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852616,0.01003068,0.0004666389,0.001017797,0.00007805172,0.002220647,0.0003028892,0.00008813469,0.0005336197],"genre_scores_gemma":[0.9964361,0.0008751217,0.0009845764,0.0003229625,0.000176163,0.0001965791,0.0004949151,0.000170176,0.0003434583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01117451,"threshold_uncertainty_score":0.9995744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105840084563498,"score_gpt":0.3148769783619751,"score_spread":0.2838185775163401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}