{"id":"W2108528869","doi":"10.1182/blood-2013-08-520387","title":"Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; British Heart Foundation; Wellcome Trust","keywords":"Platelet; Ristocetin; Medicine; Platelet activation; Aspirin; Population; Internal medicine; Predictive value; Bleeding time; Thromboxane; Epinephrine; Thrombin; Gastroenterology; Immunology; Platelet aggregation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041589,0.0001382258,0.0003680633,0.000127925,0.00003420308,0.00001133675,0.00004878841,0.00009562307,0.0000246347],"category_scores_gemma":[0.000105819,0.0001187617,0.00009735308,0.0002221278,0.00003958129,0.0003289297,0.00002061651,0.00009270853,0.000002670542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001351239,"about_ca_system_score_gemma":0.00002842422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006173411,"about_ca_topic_score_gemma":0.000001490916,"domain_scores_codex":[0.9988947,0.00008208893,0.0002981228,0.0002141303,0.0003610469,0.0001499177],"domain_scores_gemma":[0.9992447,0.0000768995,0.0002162775,0.0002334016,0.0001731836,0.00005556086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002119388,0.001727637,0.8192788,0.0002414596,0.0005931379,0.000009117569,0.0003449949,0.0007900623,0.1633069,0.0001586773,0.000001984207,0.01142779],"study_design_scores_gemma":[0.01226382,0.0006693528,0.6953006,0.0005469278,0.0001822131,0.000004318476,0.00003386781,0.0007905578,0.2899118,0.000006728604,0.0001533481,0.0001364845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858149,0.00001407796,0.01362794,0.00001520525,0.00002720082,0.0004147528,0.00001764175,0.00002952032,0.00003878343],"genre_scores_gemma":[0.9971005,0.00002953217,0.002278402,0.00004436892,0.00006339137,0.00001150546,0.0004352494,0.00002641558,0.00001059953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1266048,"threshold_uncertainty_score":0.4842963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376953836247841,"score_gpt":0.2010717620746238,"score_spread":0.1873022237121454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}