{"id":"W2108552490","doi":"10.1128/jvi.01890-10","title":"The E4orf6/E1B55K E3 Ubiquitin Ligase Complexes of Human Adenoviruses Exhibit Heterogeneity in Composition and Substrate Specificity","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Biology; DNA ligase; Cullin; Ubiquitin; Adenoviridae; Plasmid; Molecular biology; Cell biology; Virology; DNA; Genetics; Gene; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008608587,0.0001197973,0.000241072,0.00009423594,0.0001141925,0.00002284815,0.0002820401,0.0001556026,0.00002339548],"category_scores_gemma":[0.00004088802,0.00009140851,0.00008659105,0.00006427418,0.0004713978,0.00000715755,0.00008390874,0.0003953699,0.00000138093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009369366,"about_ca_system_score_gemma":0.00007459846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002072587,"about_ca_topic_score_gemma":0.002841519,"domain_scores_codex":[0.9987185,0.0002565063,0.0004775392,0.0001570016,0.0001562642,0.0002341774],"domain_scores_gemma":[0.9991636,0.00006127977,0.0003184253,0.0002345341,0.0001389656,0.000083256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001901033,0.0001377014,0.01793674,0.000008602326,0.00004531405,0.00001440111,0.00002949255,0.00003038187,0.9792195,0.0001351662,0.00008512322,0.0004565544],"study_design_scores_gemma":[0.0008775517,0.00283645,0.07108605,0.000008297532,0.00000987771,0.0001420318,0.00003301638,0.00001131505,0.924174,0.0003887874,0.0003565914,0.00007608173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983009,0.0009570628,0.00001870162,0.000462596,0.00009664472,0.00009967207,0.00001266922,0.000001775584,0.00004998732],"genre_scores_gemma":[0.9991295,0.0003867291,0.00008906169,0.0001353348,0.0002299775,0.000002301349,0.000006495755,0.00001275513,0.000007840378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05504553,"threshold_uncertainty_score":0.3727531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540394158687007,"score_gpt":0.3249974655804324,"score_spread":0.2995935239935623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}