{"id":"W2108552490","doi":"10.1128/jvi.01890-10","title":"The E4orf6/E1B55K E3 Ubiquitin Ligase Complexes of Human Adenoviruses Exhibit Heterogeneity in Composition and Substrate Specificity","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Biology; DNA ligase; Cullin; Ubiquitin; Adenoviridae; Plasmid; Molecular biology; Cell biology; Virology; DNA; Genetics; Gene; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003667058,0.0004059953,0.0003512728,0.0005268614,0.0002122576,0.0007155143,0.0001794554,0.0002564941,0.0007692632],"category_scores_gemma":[0.0003482531,0.0003168925,0.0005001029,0.000324637,0.000236446,0.0003196732,0.0003100898,0.0003094701,0.0004512827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006769084,"about_ca_system_score_gemma":0.0002049367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155326,"about_ca_topic_score_gemma":0.0009485282,"domain_scores_codex":[0.9995839,0.00004992181,0.000078192,0.0001132415,0.0001059921,0.00006881967],"domain_scores_gemma":[0.9997725,0.00003362938,0.00007613457,0.00003591462,0.00004234001,0.00003953691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001490832,0.00001227122,0.004870736,0.00004474235,0.00002110088,0.00006748309,0.00005853199,0.0001093841,0.9911307,0.0001801022,0.00002524329,0.003330573],"study_design_scores_gemma":[0.0000128134,0.0001900716,0.05435735,0.00001120537,0.00005434084,0.001571605,0.00014407,0.001170772,0.935465,0.0002166795,0.006785694,0.00002045443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942473,0.001211693,0.003510736,0.00003199157,0.000007316287,0.00001777142,0.0003371716,0.00002826236,0.0006076213],"genre_scores_gemma":[0.9904662,0.0005997758,0.006024259,0.00003481624,0.000004248384,0.00001558581,0.001369488,0.00002686014,0.001458779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155326,"threshold_uncertainty_score":0.004911363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540394158687007,"score_gpt":0.3249974655804324,"score_spread":0.2995935239935623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}