{"id":"W2108585358","doi":"10.1158/1535-7163.mct-12-1012","title":"Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"","keywords":"Antibody; Antigen; Bispecific antibody; Fragment crystallizable region; Fc receptor; Monoclonal antibody; Cytotoxic T cell; Chemistry; Antibody-dependent cell-mediated cytotoxicity; Carcinoembryonic antigen; Receptor; Cytotoxicity; Peripheral blood mononuclear cell; Molecular biology; Cancer research; Biology; Immunology; In vitro; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544969,0.000363858,0.0001654455,0.0001967353,0.00005926265,0.0002045356,0.0003186943,0.0003466362,0.0007265339],"category_scores_gemma":[0.00009727705,0.0001269532,0.0001989937,0.0001148878,0.000131814,0.0002640107,0.0001723446,0.0004139478,0.0003040791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089317,"about_ca_system_score_gemma":0.00008837908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001261567,"about_ca_topic_score_gemma":0.0002240328,"domain_scores_codex":[0.9998757,0.00001687967,0.000009383125,0.00003494096,0.00003507932,0.00002802858],"domain_scores_gemma":[0.9999238,0.000008620863,0.00003364236,0.000008047545,0.00001053263,0.00001541979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005555804,0.00003776194,0.00007732406,0.00003788404,0.000005740658,0.00001808306,0.000007714939,0.000176605,0.9967753,0.0001309048,0.00003086405,0.002646279],"study_design_scores_gemma":[0.00002526829,0.0005068514,0.0008068147,0.00000344368,0.00001274139,0.0001296262,0.000005683395,0.0008574327,0.9951823,0.00002349263,0.002442113,0.000004163064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778235,0.002251036,0.01745678,0.00006107425,0.00003147022,0.00005993868,0.0001319683,0.0001151799,0.002069026],"genre_scores_gemma":[0.9886599,0.0007722696,0.007756565,0.00008129631,0.00001104403,0.00006132794,0.0003305551,0.00001637102,0.002310653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007265339,"threshold_uncertainty_score":0.002430439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0477747923252392,"score_gpt":0.3206187296953508,"score_spread":0.2728439373701116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}