{"id":"W2108595427","doi":"10.1172/jci32727","title":"Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"University of California, San Diego; Medical Research Council; Korea Science and Engineering Foundation; Dong-A University; Imperial College London; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Cancer Research UK; University of Pittsburgh","keywords":"Oncolytic virus; Vaccinia; Systemic administration; In vivo; Cancer; Cancer cell; Cancer research; Ex vivo; Virology; Biology; Medicine; Immunology; Virus; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003252631,0.0004185235,0.0002842265,0.000224359,0.0001749229,0.0004885442,0.0002874128,0.000303717,0.000495895],"category_scores_gemma":[0.0002160703,0.0001833271,0.0002642945,0.0001635935,0.0003128117,0.0002392775,0.0002620541,0.0006831406,0.0002664698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557844,"about_ca_system_score_gemma":0.0003781212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003511764,"about_ca_topic_score_gemma":0.0005701318,"domain_scores_codex":[0.9997928,0.00003564584,0.00002443759,0.00003744405,0.00008040863,0.00002933383],"domain_scores_gemma":[0.9998751,0.00002517695,0.00004969041,0.00001760627,0.00001502883,0.0000173785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004346732,0.00005506051,0.0001766993,0.00002522571,0.000003704922,0.000059914,0.00001702044,0.0004812116,0.9956822,0.0005966095,0.00004057229,0.002818323],"study_design_scores_gemma":[0.00003084987,0.0004424975,0.0007081088,0.000008366545,0.00001230754,0.0003809459,0.00002014704,0.001735911,0.992187,0.00009890192,0.004368619,0.000006315387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530987,0.0008882715,0.04227377,0.0001449922,0.00005206486,0.0002946715,0.0004040335,0.0001676851,0.002675687],"genre_scores_gemma":[0.939081,0.001412981,0.05469159,0.00005561896,0.00001282868,0.0001440669,0.0006397562,0.00008960781,0.003872636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000495895,"threshold_uncertainty_score":0.001855791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02754542964860815,"score_gpt":0.3584723242434685,"score_spread":0.3309268945948604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}