{"id":"W2108598528","doi":"10.1016/j.currproblcancer.2009.10.002","title":"Epidermal Growth Factor Receptor Inhibitors: Current Status and Future Directions","year":2009,"lang":"en","type":"review","venue":"Current Problems in Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Gefitinib; In vivo; Epidermal growth factor receptor; Medicine; Apoptosis; Pharmacology; Lapatinib; IC50; In vitro; Epidermal growth factor; Prodrug; Growth inhibition; Receptor; Cancer research; Biochemistry; Cancer; Internal medicine; Chemistry; Biology; Trastuzumab; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100869,0.0009466598,0.002004855,0.001665627,0.0002312435,0.001376035,0.001006247,0.001108515,0.005039914],"category_scores_gemma":[0.001084751,0.0003203389,0.0005785399,0.002196732,0.0005202886,0.001804923,0.0005636023,0.002146742,0.002340036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006558901,"about_ca_system_score_gemma":0.001233174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009649019,"about_ca_topic_score_gemma":0.003152133,"domain_scores_codex":[0.9997717,0.000037487,0.00004193631,0.00004204683,0.00008165283,0.00002520279],"domain_scores_gemma":[0.9993888,0.0003237522,0.0001050219,0.00001306447,0.0001133675,0.00005589982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001794756,0.0000987069,0.000215436,0.008530611,0.0001010489,0.0001701673,0.00002653141,0.0003992831,0.0009161851,0.001603681,0.03245908,0.9552999],"study_design_scores_gemma":[0.0001064445,0.0001989685,0.000984279,0.00330685,0.0003389361,0.001202638,0.00006615261,0.000226027,0.0004859895,0.001563661,0.9914967,0.00002334897],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001284717,0.9983936,0.0001124521,0.0003997213,0.0002018413,0.000004124305,0.00002025378,0.000008907752,0.0007306381],"genre_scores_gemma":[0.0006337843,0.9981498,0.0002351339,0.0002913697,0.0001971874,0.000005193363,0.00003070354,0.000001538224,0.0004552655],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005039914,"threshold_uncertainty_score":0.01686013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05871859868774859,"score_gpt":0.4105521500524492,"score_spread":0.3518335513647006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}