{"id":"W2108600049","doi":"10.1128/aac.02590-14","title":"Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic Antimicrobial Peptides and Increases Resistance to Outer Membrane Perturbation","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Bordetella pertussis; Lipid A; Bacterial outer membrane; Microbiology; Glucosamine; Lipopolysaccharide; Cathelicidin; Antimicrobial; Antimicrobial peptides; Immune system; Chemistry; Bacteria; Biology; Biochemistry; Immunology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094755,0.0002200031,0.0001686145,0.0001697278,0.0001133422,0.000254036,0.0001271178,0.0002432301,0.001146248],"category_scores_gemma":[0.0001371231,0.0001054218,0.0002237173,0.0001188988,0.0001793579,0.0001311267,0.0001901948,0.0004749885,0.0002249419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206512,"about_ca_system_score_gemma":0.000154527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000900396,"about_ca_topic_score_gemma":0.000903876,"domain_scores_codex":[0.9998211,0.00004427756,0.00001614774,0.00002078046,0.00004369565,0.0000539943],"domain_scores_gemma":[0.9998841,0.00001853074,0.00003078436,0.00001846071,0.00001265907,0.00003543056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001036825,0.00002391948,0.0001324996,0.000006087842,0.000001982911,0.00001793615,0.00000558385,0.000009448441,0.9993312,0.00001646672,0.00001182891,0.0003394393],"study_design_scores_gemma":[0.00001796894,0.0008734217,0.0121993,0.000005033876,0.00001884569,0.0002107346,0.00003796168,0.0002760558,0.9850738,0.00003432441,0.0012475,0.000005106137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984639,0.0002833777,0.0003293553,0.00008227013,0.00001388502,0.000006589238,0.00006062507,0.00001494436,0.0007451217],"genre_scores_gemma":[0.9979163,0.0002095389,0.0004502125,0.00005617621,0.000005796576,0.000006344244,0.000136199,0.000006717025,0.001212842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146248,"threshold_uncertainty_score":0.003834605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116921317570704,"score_gpt":0.234055609586799,"score_spread":0.222886396411092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}