{"id":"W2108620598","doi":"10.1002/bit.20416","title":"Separation of monoclonal antibody alemtuzumab monomer and dimers using ultrafiltration","year":2005,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Diafiltration; Ultrafiltration (renal); Membrane; Monomer; Chromatography; Chemistry; Polyvinylidene fluoride; Monoclonal antibody; Dimer; Yield (engineering); Separation process; Selectivity; Membrane technology; Chemical engineering; Microfiltration; Polymer; Materials science; Organic chemistry; Biochemistry; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000865215,0.00007713323,0.00008003809,0.00005515874,0.00003787174,0.00000533824,0.00004036516,0.0002291547,0.0000025446],"category_scores_gemma":[0.00001846604,0.0000773112,0.00001662056,0.0000557502,0.0001065925,0.00000728953,0.0000243306,0.00006175233,3.247115e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000658109,"about_ca_system_score_gemma":0.00001316083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006640792,"about_ca_topic_score_gemma":0.000003655061,"domain_scores_codex":[0.9995615,0.000008701412,0.0001316096,0.0001748092,0.00003278844,0.00009060839],"domain_scores_gemma":[0.9997932,0.000003393902,0.00003986667,0.0001193379,0.00002052791,0.00002361957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001512212,0.00001309714,0.001628496,0.0000118507,0.00001772887,9.513025e-8,0.00001445689,0.000258044,0.9917931,0.0005892956,0.000001425996,0.005657276],"study_design_scores_gemma":[0.0001950846,0.00007988211,0.006650094,0.000005474345,0.00001065051,0.0000197826,0.00002765859,0.01275528,0.9773459,0.00001886196,0.00278712,0.0001042255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738613,0.002231246,0.02345193,0.0002855243,0.00002312632,0.00009685769,0.000006859486,0.00002003608,0.00002305968],"genre_scores_gemma":[0.9933517,0.0004487313,0.006111246,0.00001494518,0.00003080216,0.000003528022,0.0000251743,0.000004982603,0.000008904824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01949032,"threshold_uncertainty_score":0.3152659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009398072234904907,"score_gpt":0.2732072807930278,"score_spread":0.2638092085581228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}