{"id":"W2108646201","doi":"10.1101/gad.259796.115","title":"Hypoxia drives transient site-specific copy gain and drug-resistant gene expression","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Janssen Biotech; National Center for Chronic Disease Prevention and Health Promotion; Canadian Institutes of Health Research; American Cancer Society; American Lung Association; Ministero dello Sviluppo Economico; Canada Foundation for Innovation; National Institute of General Medical Sciences; Ontario Genomics Institute; National Institutes of Health; Ontario Genomics; Rivkin Center for Ovarian Cancer; Wellcome Trust; Eli Lilly and Company; Genome Canada; Ontario Ministry of Economic Development and Innovation; National Cancer Institute; Novartis Foundation; Wellcome; Massachusetts General Hospital; GlaxoSmithKline; Boehringer Ingelheim; Natural Sciences and Engineering Research Council of Canada; Pfizer; Takeda Pharmaceutical Company; AbbVie; Canadian Lung Association; Jane Coffin Childs Memorial Fund for Medical Research; Leukemia and Lymphoma Society","keywords":"Biology; Copy-number variation; Gene duplication; Gene; Hypoxia (environmental); Zebrafish; Cancer research; Tumor hypoxia; Genetics; Molecular biology; Genome; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006389924,0.0001510336,0.0001418161,0.0001247254,0.00009023108,0.0001631043,0.0001212821,0.0001523776,0.001370267],"category_scores_gemma":[0.0001173374,0.0001503058,0.0001552298,0.00009591236,0.0001706134,0.0001168953,0.0002198808,0.0002480307,0.0002546427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002623764,"about_ca_system_score_gemma":0.0001173128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005825956,"about_ca_topic_score_gemma":0.001183559,"domain_scores_codex":[0.9999187,0.000008930766,0.000006029509,0.00002269555,0.00002798851,0.00001560585],"domain_scores_gemma":[0.9999118,0.00002370762,0.00002819407,0.0000169738,0.000006014674,0.00001333092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002570665,0.000004729825,0.0003064751,0.000007174056,0.000002445818,0.00003833013,0.000007165339,0.0000502785,0.998744,0.00006644255,0.00001930294,0.0007279003],"study_design_scores_gemma":[0.000005538593,0.0001733919,0.009017024,0.000001504072,0.000007218755,0.0004794782,0.00001611686,0.0008615468,0.9880058,0.00008282886,0.001347086,0.000002502343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933395,0.0005142058,0.004475348,0.00007124244,0.0000110098,0.00002744549,0.0003036874,0.0001255787,0.001132066],"genre_scores_gemma":[0.9967946,0.000214976,0.001267778,0.00001826071,0.0000038178,0.0000144179,0.0003311491,0.00001721072,0.001337739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370267,"threshold_uncertainty_score":0.004584074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408988460219798,"score_gpt":0.2231681785065117,"score_spread":0.2090782939043137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}