{"id":"W2108660154","doi":"10.1038/ni.1720","title":"Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection","year":2009,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":451,"is_retracted":false,"has_abstract":false,"ca_institutions":"Caprion (Canada); Université de Montréal","funders":"National Eye Institute","keywords":"MHC class I; Antigen processing; Antigen presentation; Major histocompatibility complex; Biology; MHC restriction; CD74; Cell biology; CD8; Cross-presentation; MHC class II; Autophagy; Antigen; Virology; T cell; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002886309,0.0002954716,0.0004726857,0.0002686288,0.0003220252,0.0006669111,0.0001703915,0.0003580349,0.00153655],"category_scores_gemma":[0.0002875965,0.0002056279,0.0003938103,0.0001821409,0.0004011314,0.0005373562,0.0004085482,0.0009424741,0.0004892297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007707631,"about_ca_system_score_gemma":0.0004352005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005226533,"about_ca_topic_score_gemma":0.0006550583,"domain_scores_codex":[0.9997151,0.00004968517,0.00002537162,0.00002976012,0.00005116427,0.000128816],"domain_scores_gemma":[0.9997527,0.00006946474,0.00003702077,0.00004005233,0.00003177039,0.00006887108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000938135,0.00004813685,0.0003854668,0.00006384619,0.000008187008,0.0001259441,0.00003469397,0.00007181014,0.9970376,0.0002378131,0.0001029187,0.0009453856],"study_design_scores_gemma":[0.00004915104,0.0002791443,0.01143924,0.00001725459,0.00002513396,0.0003728268,0.0001423924,0.0007138758,0.9853765,0.0002440012,0.001331275,0.000009181857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996226,0.001468289,0.0003250504,0.0001040013,0.00006300344,0.000009416755,0.0001500532,0.00003065688,0.001623454],"genre_scores_gemma":[0.9972227,0.0005688278,0.0003486939,0.00004572031,0.00002320796,0.00001529276,0.0002023774,0.00001862134,0.001554554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153655,"threshold_uncertainty_score":0.005592287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009561923916913039,"score_gpt":0.2729645040819054,"score_spread":0.2634025801649924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}