{"id":"W2108689162","doi":"10.1016/j.jmb.2010.06.006","title":"The Occluding Loop of Cathepsin B Prevents Its Effective Inhibition by Human Kininogens","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; McGill University; Montreal Children's Hospital; Biotechnology Research Institute; McGill University Health Centre","funders":"","keywords":"Cathepsin O; Cathepsin B; Cathepsin H; Cathepsin A; Chemistry; Cathepsin S; Biochemistry; Cathepsin L1; Cathepsin L; Cathepsin; Cathepsin E; Cystatin; Kininogen; High-molecular-weight kininogen; Cathepsin C; Molecular biology; Biology; Enzyme; Kallikrein; Cystatin C","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003236033,0.0002193163,0.0003713785,0.0001509515,0.0001647285,0.0003194094,0.0002949962,0.0004213642,0.001495397],"category_scores_gemma":[0.0005641265,0.00020188,0.0002445448,0.00009140366,0.0003477094,0.0001925897,0.0001987688,0.0005746999,0.0004058958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002260696,"about_ca_system_score_gemma":0.0002760036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004174381,"about_ca_topic_score_gemma":0.0003525895,"domain_scores_codex":[0.9998115,0.00004055437,0.00001882997,0.00002076116,0.00003878481,0.00006966681],"domain_scores_gemma":[0.9996333,0.0001584573,0.00007208779,0.00004811245,0.000018565,0.00006940268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002199016,0.0001528774,0.0006013262,0.00009623214,0.00004189431,0.0002902168,0.00005882306,0.0002164232,0.9909393,0.0006719464,0.0001878715,0.00454409],"study_design_scores_gemma":[0.0002319836,0.0007094421,0.003912347,0.00001681915,0.00003346423,0.001216817,0.00001716184,0.00159904,0.9887667,0.0001335202,0.003350937,0.00001174688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969063,0.001338834,0.001003269,0.00007490389,0.00002721691,0.00001277603,0.00005693563,0.00002813485,0.0005516338],"genre_scores_gemma":[0.9981229,0.0003416637,0.0006189145,0.00004800623,0.00001409407,0.000008171412,0.0001498913,0.00001060497,0.0006858738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495397,"threshold_uncertainty_score":0.005002558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009416503441604619,"score_gpt":0.3104024645046631,"score_spread":0.3009859610630585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}