{"id":"W2108729187","doi":"10.1158/1078-0432.ccr-03-0774","title":"Mcl-1 Is a Novel Therapeutic Target for Human Sarcoma","year":2004,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Oesterreichische Nationalbank; Kamillo Eisner Stiftung; Universität Wien; Austrian Science Fund","keywords":"Apoptosis; Terminal deoxynucleotidyl transferase; Saline; TUNEL assay; Sarcoma; Immunohistochemistry; Cyclophosphamide; Cancer research; Medicine; Oligonucleotide; Biology; Pathology; Chemotherapy; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00109954,0.0000942679,0.000143221,0.00003977945,0.0002183584,0.00002939251,0.0002287609,0.0002311055,0.0001076365],"category_scores_gemma":[0.00007638762,0.0000790437,0.0001686099,0.0001002436,0.0001787746,0.000002459064,0.0001056204,0.0002043265,0.00001198969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003469231,"about_ca_system_score_gemma":0.0002277572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001178232,"about_ca_topic_score_gemma":0.000100623,"domain_scores_codex":[0.9986417,0.00005718419,0.000274966,0.0004274104,0.0002375531,0.0003611582],"domain_scores_gemma":[0.9991955,0.00004550897,0.0000426718,0.0003400831,0.0002563076,0.0001199459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003425485,0.0004064072,0.00114841,0.00004644902,0.00009588547,8.895567e-7,0.00004489818,0.000095398,0.9663791,0.007220051,0.003030876,0.0211891],"study_design_scores_gemma":[0.005552887,0.003049959,0.007883134,0.00004761147,0.00002324453,0.000003206025,0.00005741105,0.000140373,0.3392867,0.04447518,0.5991472,0.0003331295],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567194,0.003386864,0.03367986,0.003984923,0.000450991,0.001010783,0.00008740444,0.00001948542,0.0006602588],"genre_scores_gemma":[0.9931026,0.0004685991,0.001557982,0.0006533393,0.001087939,0.0001652879,0.00007226574,0.00003024517,0.002861807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6270924,"threshold_uncertainty_score":0.3223309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2572669998544351,"score_gpt":0.5329620560572201,"score_spread":0.2756950562027851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}