{"id":"W2108752404","doi":"10.1093/nar/gks1470","title":"MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils","year":2013,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Somatic hypermutation; Gene conversion; Immunoglobulin class switching; Pseudogene; Genetics; Immunoglobulin gene; DNA mismatch repair; Minichromosome; Antibody; B cell; Gene; Molecular biology; Recombination; DNA repair; Chromatin; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000678518,0.0006730273,0.0003005891,0.0003241165,0.0001534023,0.0001936038,0.0002937266,0.0004994787,0.002470566],"category_scores_gemma":[0.00007610567,0.0002109983,0.0003225328,0.0001675319,0.0002115878,0.0001247878,0.0002377858,0.0005472247,0.0009095646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087537,"about_ca_system_score_gemma":0.0001137499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008761742,"about_ca_topic_score_gemma":0.0007478159,"domain_scores_codex":[0.999831,0.00002653521,0.00002847501,0.00004700964,0.00003924455,0.00002776268],"domain_scores_gemma":[0.9997804,0.00004314221,0.00006069603,0.00004521964,0.000009821416,0.00006082913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056677,0.00001511295,0.0001744567,0.00003098625,0.000004834457,0.0001233512,0.00001061611,0.00004151511,0.9988883,0.00004148827,0.00002838603,0.0005352867],"study_design_scores_gemma":[0.00001214466,0.0002497618,0.004480582,0.000004414585,0.0000100981,0.0006995086,0.00001979045,0.0002448497,0.9924792,0.00002295691,0.001773289,0.0000033695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946832,0.001151448,0.001054545,0.00006629203,0.00003674852,0.00002991337,0.001276281,0.0002203747,0.001481171],"genre_scores_gemma":[0.9915698,0.0006788489,0.0013117,0.00003613554,0.00001309247,0.00004059083,0.00142224,0.00006432397,0.004863323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002470566,"threshold_uncertainty_score":0.00826484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05817593734913241,"score_gpt":0.3155266832429663,"score_spread":0.2573507458938339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}