{"id":"W2108821770","doi":"10.1172/jci38902","title":"The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Ottawa Regional Cancer Foundation; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; University of California, San Francisco; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; University of Missouri","keywords":"T cell; Histone deacetylase; Experimental autoimmune encephalomyelitis; Autoimmunity; Sirtuin 1; Peripheral tolerance; Cell biology; Biology; Immunology; Transcription factor; Downregulation and upregulation; Immune tolerance; Cancer research; Histone; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002889718,0.0005381813,0.0004110983,0.0008106615,0.0002747581,0.0005069113,0.0004934105,0.000586136,0.002006395],"category_scores_gemma":[0.0002043504,0.0004317299,0.000430139,0.0002901736,0.0005189981,0.0002756644,0.0003059982,0.00109269,0.0008890477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221234,"about_ca_system_score_gemma":0.0003042755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005017328,"about_ca_topic_score_gemma":0.0007509027,"domain_scores_codex":[0.9996481,0.0000637695,0.00003274575,0.00009103521,0.00009475504,0.00006956844],"domain_scores_gemma":[0.9996341,0.00002398078,0.0001613804,0.00004796209,0.00002842091,0.0001042097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002485932,0.00003429508,0.000321906,0.00004283832,0.00001324561,0.00007471891,0.00001452429,0.00006226671,0.996191,0.0002033999,0.0001037259,0.002689483],"study_design_scores_gemma":[0.0001298579,0.0008249978,0.01119732,0.00002996689,0.0001005891,0.0008670835,0.00004620579,0.001473466,0.9726438,0.0004135499,0.01225147,0.0000216154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766747,0.004425535,0.01241908,0.0005943361,0.0001510633,0.00007405988,0.001235924,0.000895428,0.003530005],"genre_scores_gemma":[0.9858686,0.002083065,0.005824662,0.0001701385,0.00004821962,0.00007376184,0.0009557884,0.0001162818,0.004859496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006395,"threshold_uncertainty_score":0.006712019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04355535484365589,"score_gpt":0.390076059127944,"score_spread":0.3465207042842881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}