{"id":"W2108822341","doi":"10.1084/jem.20122516","title":"The TAL1 complex targets the <i>FBXW7</i> tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia","year":2013,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute; National Institutes of Health; Kay Kendall Leukaemia Fund; Japan Society for the Promotion of Science; William Lawrence and Blanche Hughes Foundation; American Society of Hematology","keywords":"Gene knockdown; Biology; Chromatin immunoprecipitation; Transcription factor; microRNA; Cancer research; Chromatin; GATA3; DNA methylation; Cell biology; Gene expression; Promoter; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038445,0.0001746343,0.0002000555,0.00002406089,0.0002692321,0.00002714501,0.0006549956,0.00004398995,0.0001309077],"category_scores_gemma":[0.00004425366,0.00007562397,0.00007079908,0.00006266929,0.0003304164,0.00001356203,0.0001398903,0.0002126232,0.000008636341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006596445,"about_ca_system_score_gemma":0.00004385774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002309184,"about_ca_topic_score_gemma":0.00001051021,"domain_scores_codex":[0.9987449,0.0001624523,0.0004504181,0.0001181159,0.0002539461,0.0002701474],"domain_scores_gemma":[0.9991359,0.0001076304,0.0003355354,0.0002670342,0.00007953147,0.00007439119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001335581,0.00005339642,0.00004537126,0.00000237309,0.00005244174,0.000004795902,0.0006039519,0.00001193953,0.9263691,0.000003170293,0.07261454,0.0001053053],"study_design_scores_gemma":[0.001461754,0.001173795,0.0004887573,0.00005374189,0.00002582462,0.0001332067,0.005152614,0.0000960037,0.9869936,0.00004091639,0.004281417,0.00009836916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910917,0.006348904,0.0000477351,0.001205159,0.0002180951,0.0002066621,0.000003941139,0.000002280769,0.0008755529],"genre_scores_gemma":[0.9977279,0.0002112001,0.00002026801,0.001225741,0.0003713188,0.00001436062,0.00001213492,0.00001715043,0.000399934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06833312,"threshold_uncertainty_score":0.3083856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087797565080607,"score_gpt":0.2673903049143042,"score_spread":0.2565123292634982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}