{"id":"W2108883303","doi":"10.1038/mt.2011.276","title":"The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Terry Fox Foundation","keywords":"Oncolytic virus; Vaccinia; Biology; Virology; Cancer research; Cancer; Gene; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002876326,0.0002808264,0.000235074,0.00008636753,0.0001198091,0.00004010415,0.0004537604,0.0001849883,0.00002088053],"category_scores_gemma":[0.00001678466,0.0002356015,0.00006678996,0.0003230479,0.0002223673,0.000006278196,0.00008217124,0.000279573,0.00000399701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745963,"about_ca_system_score_gemma":0.0003328386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002173798,"about_ca_topic_score_gemma":0.003965739,"domain_scores_codex":[0.9979736,0.0003579225,0.0002852198,0.0005986911,0.0002024971,0.0005821205],"domain_scores_gemma":[0.9991303,0.00003182414,0.00009925603,0.0005488865,0.00007120126,0.0001184943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002042337,0.0001010961,0.006052459,0.00000446019,0.00009337724,0.00002298048,0.0003572446,0.0001630154,0.9707067,0.000004780761,0.0001437936,0.02030774],"study_design_scores_gemma":[0.0017075,0.001511048,0.00858574,0.00001703794,0.000004275607,0.00000437903,0.0000901156,0.0001798731,0.9860824,0.0001552475,0.001382399,0.0002799605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876504,0.01116033,0.00006834264,0.0001390259,0.00003893347,0.0007026383,0.00002687315,0.00001489636,0.0001985523],"genre_scores_gemma":[0.9890153,0.009817254,0.000123656,0.0005114566,0.00002472364,0.0003551944,0.00001618228,0.00006854141,0.00006765876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02002778,"threshold_uncertainty_score":0.9607552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357912093871324,"score_gpt":0.2766259929282771,"score_spread":0.2530468719895638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}