{"id":"W2108912009","doi":"10.1073/pnas.1018224108","title":"Immature T-cell clustering and efficient differentiation require the polarity protein Scribble","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Biology; Cell polarity; Cellular differentiation; T cell; Progenitor cell; Thymocyte; Cell; Stem cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001255577,0.00007113765,0.0001044158,0.00008593622,0.000264093,0.00003566626,0.000383492,0.00008907627,0.00001956586],"category_scores_gemma":[0.0004093984,0.00003653842,0.00004695063,0.0004422216,0.0007055586,0.0001359377,0.0002539624,0.0004516488,9.081798e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001740639,"about_ca_system_score_gemma":0.00003765994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000859883,"about_ca_topic_score_gemma":1.620438e-7,"domain_scores_codex":[0.9981936,0.000006358154,0.0001966384,0.0001904801,0.00127401,0.0001388889],"domain_scores_gemma":[0.9994218,0.00005408899,0.000193285,0.00001289358,0.0002729298,0.00004495911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004564874,0.00004651739,0.002094066,0.0001720686,0.000004375215,6.892328e-9,0.000109773,0.0000045187,0.9931022,0.004123892,0.00005015091,0.0002468037],"study_design_scores_gemma":[0.000273483,0.00004837754,0.2020273,0.0001242131,0.00001108172,0.00001447943,0.0001591557,0.008145591,0.7858738,0.003143774,0.0001316482,0.00004713022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98823,0.0000982598,0.00000289373,0.008504713,0.00001457062,0.0004265162,0.000003677687,0.000007373706,0.002712027],"genre_scores_gemma":[0.9982698,0.000008361196,0.001062806,0.0001026379,0.00005029892,0.000009939033,1.232276e-7,0.000003739133,0.0004922894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2072284,"threshold_uncertainty_score":0.259966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904828659564859,"score_gpt":0.3108362516093132,"score_spread":0.2817879650136646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}