{"id":"W2108912009","doi":"10.1073/pnas.1018224108","title":"Immature T-cell clustering and efficient differentiation require the polarity protein Scribble","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Biology; Cell polarity; Cellular differentiation; T cell; Progenitor cell; Thymocyte; Cell; Stem cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006597673,0.0002005344,0.00016903,0.0001216993,0.0001831052,0.0003363692,0.0001059768,0.0001849566,0.0007051549],"category_scores_gemma":[0.0001394062,0.0001148315,0.0001041509,0.00009682542,0.0001433903,0.0001619468,0.0002356302,0.0005165531,0.0007460063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202589,"about_ca_system_score_gemma":0.0002108272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004053299,"about_ca_topic_score_gemma":0.0007397778,"domain_scores_codex":[0.9999044,0.00001290299,0.000007628471,0.00001673339,0.00003364661,0.00002474403],"domain_scores_gemma":[0.9998612,0.0000136114,0.00004619844,0.00001860423,0.00001756712,0.00004277835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001850176,0.000003055748,0.00007694222,0.000005771591,7.528402e-7,0.00002048167,0.000004184906,0.00002514171,0.9992299,0.00004317257,0.00001193462,0.0005602843],"study_design_scores_gemma":[0.000008351179,0.00007331135,0.009730914,0.000003280696,0.000007048035,0.0005242808,0.00002805856,0.000823758,0.985727,0.0001074302,0.002963146,0.000003388764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896604,0.001359672,0.006956087,0.00005281787,0.000006719915,0.00001690176,0.0001696562,0.0001058491,0.001671801],"genre_scores_gemma":[0.9925479,0.0007426268,0.003748518,0.00003190617,0.00000559178,0.00001868709,0.0005170449,0.00003287421,0.002354791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007051549,"threshold_uncertainty_score":0.002358973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904828659564859,"score_gpt":0.3108362516093132,"score_spread":0.2817879650136646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}