{"id":"W2108932731","doi":"10.1093/hmg/ddq178","title":"Fine mapping of the association with obesity at the FTO locus in African-derived populations","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Ministerio de Economía y Competitividad","keywords":"Biology; Linkage disequilibrium; Locus (genetics); Genetics; Genetic association; Genetic admixture; Ancestry-informative marker; Single-nucleotide polymorphism; Genetic genealogy; Genome-wide association study; Evolutionary biology; FTO gene; Association mapping; Population; Genotype; Gene; Demography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003943739,0.0001344191,0.000159583,0.00003479795,0.0002085672,0.00001094062,0.0002840377,0.0001969443,0.00002388074],"category_scores_gemma":[0.000208058,0.00009137522,0.00009440902,0.0001860451,0.0001180055,0.000001287898,0.0002015923,0.0001965429,0.000003265983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004593887,"about_ca_system_score_gemma":0.00006017885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000113228,"about_ca_topic_score_gemma":0.007436559,"domain_scores_codex":[0.9988311,0.0001936891,0.0002962637,0.0002429577,0.0001843054,0.0002516766],"domain_scores_gemma":[0.9989402,0.00002516531,0.0002961653,0.0005709544,0.0001316531,0.00003589941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000003782141,0.00003136719,0.4255871,0.000002777125,0.00002579304,5.629107e-7,0.00007498587,0.00125694,0.5725325,0.0001798589,0.0002242489,0.00008005001],"study_design_scores_gemma":[0.0003380465,0.00006027629,0.9426687,0.000005549909,0.0000307834,0.000004821281,0.00005328564,0.00007276489,0.05369377,0.0006594065,0.00228672,0.0001259086],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968666,0.0001967878,0.0009072468,0.000631622,0.0001048593,0.0002781827,0.0000142217,0.000004433297,0.0009960486],"genre_scores_gemma":[0.998012,0.00001204573,0.001186584,0.0001554267,0.00005884681,0.00002426732,0.00005397143,0.00001857259,0.0004782748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5188388,"threshold_uncertainty_score":0.4149774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496074911903743,"score_gpt":0.2478759067515698,"score_spread":0.2329151576325324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}