{"id":"W2108933679","doi":"10.1093/neuonc/noq145","title":"Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas","year":2010,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Glial fibrillary acidic protein; Biology; DNA methylation; Glioma; GFAP stain; Bisulfite sequencing; Molecular biology; Methylation; Epigenetics; Cancer research; Gene silencing; Gene expression; Gene; Genetics; Immunology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009968657,0.0001491442,0.00015286,0.0002956224,0.0001085623,0.0001087358,0.00009257134,0.0001093564,0.0005971327],"category_scores_gemma":[0.0002415113,0.00008605274,0.0001158934,0.0001610447,0.000118291,0.00006111663,0.0001104608,0.0001343905,0.0001257959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541983,"about_ca_system_score_gemma":0.0001240095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185652,"about_ca_topic_score_gemma":0.001650811,"domain_scores_codex":[0.9999374,0.00001365053,0.000003962647,0.00001787186,0.00001635995,0.00001074029],"domain_scores_gemma":[0.9999381,0.00001472205,0.0000190248,0.00000662482,0.00001448362,0.000006962723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002642821,0.00002422779,0.006751471,0.00006367369,0.0000285136,0.0001910688,0.0001377398,0.0001343799,0.9831412,0.0001923381,0.00007045261,0.009000729],"study_design_scores_gemma":[0.00002834478,0.000413609,0.1688695,0.00001601442,0.000102304,0.001204962,0.0001519851,0.001627677,0.8229651,0.0004687539,0.004139703,0.00001196701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937803,0.002443866,0.002282891,0.00007425684,0.00001436641,0.00001655128,0.0002571786,0.00003742771,0.001093199],"genre_scores_gemma":[0.9976248,0.000784296,0.0007193249,0.00001756136,0.000003948539,0.00001172246,0.000172777,0.000005371513,0.0006603188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185652,"threshold_uncertainty_score":0.002357483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111158654251908,"score_gpt":0.2792365252233234,"score_spread":0.2681249386808043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}