{"id":"W2108933679","doi":"10.1093/neuonc/noq145","title":"Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas","year":2010,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Glial fibrillary acidic protein; Biology; DNA methylation; Glioma; GFAP stain; Bisulfite sequencing; Molecular biology; Methylation; Epigenetics; Cancer research; Gene silencing; Gene expression; Gene; Genetics; Immunology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004787642,0.0001849255,0.0002712829,0.0001477774,0.00006694988,0.00001126693,0.000175646,0.0004959296,0.00004518263],"category_scores_gemma":[0.0002290211,0.0001949603,0.00008559918,0.0001998304,0.0001795215,0.000007559719,0.00009610967,0.0001955715,0.000004541694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002770047,"about_ca_system_score_gemma":0.0001332712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006775351,"about_ca_topic_score_gemma":0.0003364251,"domain_scores_codex":[0.9982533,0.0002933456,0.0005415536,0.0004542273,0.0001840437,0.000273495],"domain_scores_gemma":[0.9990459,0.00004507011,0.0003077037,0.0004022765,0.0001145716,0.0000844695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009209701,0.0001024995,0.002204226,0.00001871679,0.00001010146,0.000003903991,0.00004751678,0.00008074436,0.9885345,0.0002321376,0.0001081475,0.008565475],"study_design_scores_gemma":[0.000836998,0.00107125,0.007179487,0.000007019409,0.00001406175,0.000005876137,0.00001276399,0.0001034553,0.9602975,0.001065423,0.0292326,0.0001735542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964908,0.0004547642,0.0008434255,0.0002672943,0.0003036028,0.0005327825,0.00001828025,0.00001248727,0.001076528],"genre_scores_gemma":[0.9984248,0.00007176428,0.0008393952,0.00004830648,0.0002408941,0.00004533468,0.0002282601,0.00003341622,0.00006783988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02912445,"threshold_uncertainty_score":0.795025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111158654251908,"score_gpt":0.2792365252233234,"score_spread":0.2681249386808043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}