{"id":"W2108943171","doi":"10.1016/j.chembiol.2007.10.008","title":"Inhibition of the Pathogenically Related Morphologic Transition in Candida albicans by Disrupting Cdc42 Binding to Its Effectors","year":2007,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute; University of Waterloo","funders":"National Research Council Canada; Government of Canada; Genomic Health","keywords":"Candida albicans; CDC42; Biology; Signal transduction; Effector; Corpus albicans; Cell biology; Transduction (biophysics); GTPase; Fungal protein; Transition (genetics); Microbiology; Yeast; Biochemistry; Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194184,0.0004112045,0.0002184902,0.0002619494,0.0004475622,0.0004900764,0.000364437,0.0003253015,0.001436923],"category_scores_gemma":[0.0001558633,0.0002485526,0.0002198739,0.0002178012,0.0002458627,0.0001566438,0.0002403311,0.0008059653,0.0003833532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820258,"about_ca_system_score_gemma":0.0003931008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409786,"about_ca_topic_score_gemma":0.00146623,"domain_scores_codex":[0.9998436,0.00002630266,0.00001119185,0.00001735041,0.00005305912,0.00004852489],"domain_scores_gemma":[0.999903,0.00002135176,0.00001865592,0.00001425548,0.0000132367,0.00002948449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001486972,0.00004273373,0.00005991277,0.00001565185,0.00000292938,0.00006859312,0.000008711951,0.00008827898,0.998425,0.0002814217,0.00004129404,0.0008167457],"study_design_scores_gemma":[0.000009960038,0.00005647026,0.0009755524,0.000001870356,0.000003874522,0.0001483653,0.00001802739,0.0005376188,0.9973086,0.00004541478,0.0008918892,0.000002354719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930795,0.001332398,0.00185977,0.0002097991,0.00003876062,0.00002347894,0.0001876735,0.00007159631,0.003197073],"genre_scores_gemma":[0.9963,0.0004512241,0.0009304567,0.00004197994,0.000005936785,0.00001486876,0.0001998315,0.00001389729,0.002041743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001436923,"threshold_uncertainty_score":0.004806995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008455603590575341,"score_gpt":0.2758940264514911,"score_spread":0.2674384228609157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}