{"id":"W2109003937","doi":"10.1136/bmj.g4164","title":"Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data","year":2014,"lang":"en","type":"review","venue":"BMJ","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":677,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; Deutsche Krebshilfe; National Institute on Drug Abuse; Agentschap NL; Hjärt-Lungfonden; ZonMw; National Institute on Minority Health and Health Disparities; Mayo Foundation for Medical Education and Research; Deutsche Forschungsgemeinschaft; Compagnia di San Paolo; European Commission; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Wellcome Trust; Cancer Research UK; University College London; Novo Nordisk Fonden; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Vetenskapsrådet; Ministero della Salute; Northwestern University; Economic and Social Research Council; Northwestern Memorial Foundation; World Cancer Research Fund; American Heart Association; Stockholms Läns Landsting; John D. and Catherine T. MacArthur Foundation","keywords":"Association (psychology); Disease; Mendelian inheritance; Mendelian randomization; Medicine; Computer science; Bioinformatics; Data science; Psychology; Genetics; Internal medicine; Biology; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006597914,0.0003246133,0.002919832,0.0005154728,0.0001191044,0.000055067,0.0001763727,0.0003221231,0.0001019153],"category_scores_gemma":[0.001997226,0.0002540362,0.0008544547,0.0004828096,0.0000259983,0.00005382824,0.00008350183,0.0003604935,0.00009949335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001361309,"about_ca_system_score_gemma":0.0004821005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003514401,"about_ca_topic_score_gemma":0.0000062091,"domain_scores_codex":[0.9958403,0.001253237,0.0008247604,0.0007103326,0.00104958,0.0003218115],"domain_scores_gemma":[0.9962214,0.001075913,0.0005513805,0.001611515,0.00007908577,0.0004606534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001401291,0.00006856162,0.01750781,0.01922157,0.04551305,0.00002269566,0.00002688187,0.00004080086,1.394413e-8,0.00000635426,0.01046452,0.9069876],"study_design_scores_gemma":[0.00285847,0.00003973456,0.02174269,0.002837923,0.2328982,9.063432e-7,0.000001765321,0.001804772,2.555264e-8,0.000001209989,0.7376056,0.0002086509],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005097124,0.9942425,0.0006193594,0.0009112922,0.0001192631,0.003159966,0.0006912086,0.00006970025,0.0001356676],"genre_scores_gemma":[0.002946677,0.9802498,0.0001520787,0.0005486129,0.001000465,0.0003810092,0.01450112,0.00004776164,0.000172439],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.906779,"threshold_uncertainty_score":0.9999912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3908286484699612,"score_gpt":0.4758518529295646,"score_spread":0.08502320445960337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}