{"id":"W2109003937","doi":"10.1136/bmj.g4164","title":"Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data","year":2014,"lang":"en","type":"review","venue":"BMJ","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":677,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; Deutsche Krebshilfe; National Institute on Drug Abuse; Agentschap NL; Hjärt-Lungfonden; ZonMw; National Institute on Minority Health and Health Disparities; Mayo Foundation for Medical Education and Research; Deutsche Forschungsgemeinschaft; Compagnia di San Paolo; European Commission; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Wellcome Trust; Cancer Research UK; University College London; Novo Nordisk Fonden; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Vetenskapsrådet; Ministero della Salute; Northwestern University; Economic and Social Research Council; Northwestern Memorial Foundation; World Cancer Research Fund; American Heart Association; Stockholms Läns Landsting; John D. and Catherine T. MacArthur Foundation","keywords":"Association (psychology); Disease; Mendelian inheritance; Mendelian randomization; Medicine; Computer science; Bioinformatics; Data science; Psychology; Genetics; Internal medicine; Biology; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09697504,0.003465224,0.008285323,0.002642556,0.0007652909,0.001484685,0.002770948,0.002649132,0.006819506],"category_scores_gemma":[0.1091813,0.002224501,0.01107868,0.002826238,0.001273752,0.001565995,0.001347539,0.002217539,0.0008250319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001195575,"about_ca_system_score_gemma":0.001374247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002773867,"about_ca_topic_score_gemma":0.001719033,"domain_scores_codex":[0.8865914,0.09788978,0.004119346,0.007773984,0.002598983,0.001026375],"domain_scores_gemma":[0.967985,0.02017081,0.003713219,0.006638678,0.001159177,0.000333234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.459579,0.0009036131,0.09255735,0.01035708,0.3570639,0.001172234,0.0006090101,0.01604686,0.00401865,0.004857455,0.007877167,0.04495765],"study_design_scores_gemma":[0.400892,0.01903101,0.0752861,0.001690221,0.3427967,0.00198186,0.0001918086,0.1193184,0.003864368,0.02117146,0.01324327,0.0005327767],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.444987,0.02978934,0.4453087,0.001949475,0.003130761,0.06045771,0.009117983,0.002675032,0.002584066],"genre_scores_gemma":[0.8590328,0.002052049,0.07746108,0.0006941048,0.0002434247,0.05550914,0.002434759,0.0002601002,0.002312611],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.09697504,"threshold_uncertainty_score":0.5128592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3908286484699612,"score_gpt":0.4758518529295646,"score_spread":0.08502320445960337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}