{"id":"W2109017124","doi":"10.1111/j.1600-079x.2012.00986.x","title":"Melatonin inhibits matrix metalloproteinase‐9 (MMP‐9) activation in the lipopolysaccharide (LPS)‐stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis","year":2012,"lang":"en","type":"article","venue":"Journal of Pineal Research","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Melatonin; Lipopolysaccharide; Matrix metalloproteinase; Endocrinology; Electrophoretic mobility shift assay; Internal medicine; Inflammation; In vivo; Tumor necrosis factor alpha; Chemistry; Pharmacology; Biology; Medicine; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003570147,0.0001393126,0.0003053831,0.0006032506,0.000150996,0.00008744252,0.0002361691,0.0001168415,0.00001862728],"category_scores_gemma":[0.001242106,0.00009947103,0.00006435769,0.0005103529,0.0002391703,0.0007279049,0.0001236033,0.0008792604,0.000003964769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007080154,"about_ca_system_score_gemma":0.0001651578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008151829,"about_ca_topic_score_gemma":0.000005083099,"domain_scores_codex":[0.9972066,0.0005103664,0.000532661,0.0001910827,0.00104612,0.0005131941],"domain_scores_gemma":[0.9983736,0.0007424427,0.00026535,0.0001888237,0.0001891221,0.0002406451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001754336,0.0001169334,0.0003499478,0.0000438663,0.000008874848,0.00001522957,0.002076093,0.0006082979,0.9913437,0.004282347,0.00006211335,0.00091717],"study_design_scores_gemma":[0.000996087,0.0002243101,0.0006193971,0.00008855006,0.00001233243,0.0001257035,0.0002685525,0.01192547,0.9851825,0.0003869009,0.00007747819,0.00009274033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979165,0.0006119786,0.0002988014,0.0005896459,0.00004022961,0.0003563999,0.000008370786,0.000005191389,0.0001729073],"genre_scores_gemma":[0.9986554,0.0003874009,0.0004022576,0.00004594466,0.00009671524,0.000007569512,3.482408e-7,0.00001975858,0.0003845861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01131717,"threshold_uncertainty_score":0.4056311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1038163448875537,"score_gpt":0.3687814230725223,"score_spread":0.2649650781849686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}