{"id":"W2109042013","doi":"10.3109/13693786.2010.535031","title":"Disruption of sphingolipid biosynthetic gene<i>IPT1</i>reduces<i>Candida albicans</i>adhesion and prevents activation of human gingival epithelial cell innate immune defense","year":2010,"lang":"en","type":"article","venue":"Medical Mycology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Candida albicans; TLR2; Biology; Innate immune system; Microbiology; Defensin; Beta defensin; Gene expression; Mutant; Corpus albicans; Gene; Cell biology; Molecular biology; Immune system; Immunology; Antimicrobial; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008451967,0.0002695172,0.0002127126,0.0001266722,0.0000960261,0.0002938565,0.0001887676,0.0001964955,0.0007418597],"category_scores_gemma":[0.00009354809,0.0001015058,0.0002501829,0.00009395818,0.0001881873,0.000109162,0.000163104,0.0005023085,0.000221101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123499,"about_ca_system_score_gemma":0.0001507628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008435811,"about_ca_topic_score_gemma":0.0006110753,"domain_scores_codex":[0.9998714,0.00001748086,0.00001482753,0.00002229593,0.00004183,0.00003218788],"domain_scores_gemma":[0.9999149,0.00001529121,0.00003029956,0.00001209721,0.000007277549,0.00002014132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004318632,0.00001874478,0.00008889704,0.00001051705,0.0000020417,0.00002311515,0.0000053719,0.00002420574,0.9994098,0.0000232499,0.0000104083,0.000340505],"study_design_scores_gemma":[0.000003107308,0.0001352583,0.002007125,0.000001935957,0.000006634938,0.0001031392,0.00001540645,0.0002827461,0.9968886,0.000008437288,0.0005460972,0.000001639851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997996,0.0003178146,0.0009262927,0.00004964861,0.0000104609,0.00001201798,0.0001991063,0.00003422575,0.0004546008],"genre_scores_gemma":[0.9970452,0.000262945,0.001370889,0.00002650588,0.000004821025,0.00001292983,0.0003866199,0.00001438262,0.0008756501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008435811,"threshold_uncertainty_score":0.002481818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006291157112635909,"score_gpt":0.2326626229815878,"score_spread":0.2263714658689519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}