{"id":"W2109042013","doi":"10.3109/13693786.2010.535031","title":"Disruption of sphingolipid biosynthetic gene<i>IPT1</i>reduces<i>Candida albicans</i>adhesion and prevents activation of human gingival epithelial cell innate immune defense","year":2010,"lang":"en","type":"article","venue":"Medical Mycology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Candida albicans; TLR2; Biology; Innate immune system; Microbiology; Defensin; Beta defensin; Gene expression; Mutant; Corpus albicans; Gene; Cell biology; Molecular biology; Immune system; Immunology; Antimicrobial; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004658127,0.0001931524,0.0005037221,0.0001547996,0.0001541696,0.000005292803,0.0002209573,0.0005269162,0.0009666826],"category_scores_gemma":[0.0002176142,0.0001664267,0.0001057969,0.0001011581,0.001036615,0.0000878963,0.0001702294,0.0005312045,0.00001564433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001475263,"about_ca_system_score_gemma":0.00009001472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004562465,"about_ca_topic_score_gemma":0.0000334173,"domain_scores_codex":[0.9985218,0.0002269794,0.0005383749,0.0002980619,0.00008747546,0.0003272856],"domain_scores_gemma":[0.9990374,0.0002666644,0.0003747416,0.000208121,0.00006024987,0.00005276424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001995072,0.0003540455,0.0009296002,0.00007531642,0.00005334148,0.000002699825,0.000409142,8.003702e-7,0.9936665,0.0004133402,0.000104788,0.003790957],"study_design_scores_gemma":[0.001368016,0.0004751825,0.008080152,0.00007829848,0.00005728054,0.00006309428,0.0001064124,0.00000893703,0.9881023,0.000354138,0.00115274,0.0001534807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980531,0.0001308407,0.0001045776,0.0003265302,0.0008058645,0.0002200993,0.00004350024,0.00002641372,0.0002891062],"genre_scores_gemma":[0.9991803,0.0001220976,0.0001165185,0.00009621433,0.00009441929,0.000009883331,0.00007951735,0.00001948923,0.0002815274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007150552,"threshold_uncertainty_score":0.9999466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006291157112635909,"score_gpt":0.2326626229815878,"score_spread":0.2263714658689519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}