{"id":"W2109046615","doi":"10.1002/ana.24432","title":"Suprachiasmatic neuron numbers and rest–activity circadian rhythms in older humans","year":2015,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Dana Foundation; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; U.S. Public Health Service","keywords":"Circadian rhythm; Suprachiasmatic nucleus; Light effects on circadian rhythm; Vasoactive intestinal peptide; Neuroscience; Rhythm; Endogeny; Biology; Dark therapy; Hypothalamus; Endocrinology; Alzheimer's disease; Phase response curve; Internal medicine; Psychology; Medicine; Circadian clock; Disease; Neuropeptide; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000305685,0.0001666024,0.0003177471,0.0002383732,0.00004640231,0.0000172309,0.0001554389,0.0001344715,0.00002006074],"category_scores_gemma":[0.0007177199,0.000176381,0.00005141932,0.0002724141,0.0002788769,0.0002417822,0.00008202846,0.000375634,0.00004109336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004775133,"about_ca_system_score_gemma":0.00006511022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001830525,"about_ca_topic_score_gemma":0.0001894167,"domain_scores_codex":[0.9981385,0.0004463336,0.0002743658,0.0004997753,0.0001857705,0.0004551918],"domain_scores_gemma":[0.9988931,0.0003376518,0.0001414641,0.0003470393,0.0000316767,0.0002490765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00263512,0.002702305,0.461523,0.0005420678,0.00004187038,0.007877805,0.02292099,0.001306862,0.32186,0.1374554,0.0160046,0.0251299],"study_design_scores_gemma":[0.001526425,0.0009119691,0.9327042,0.00001985404,0.000009297443,0.0006921183,0.00004111498,0.0006857736,0.04964869,0.002713332,0.01073001,0.000317256],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853487,0.0001262231,0.000006281398,0.009177107,0.0003181003,0.0002249769,0.000008059884,0.00003559162,0.004754951],"genre_scores_gemma":[0.9938439,0.0001256628,0.000007753525,0.005792384,0.00005431908,0.00001161284,7.10556e-7,0.00002433462,0.0001393151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4711812,"threshold_uncertainty_score":0.7192607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1006436953550626,"score_gpt":0.3282765969282835,"score_spread":0.2276329015732209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}