{"id":"W2109069233","doi":"10.1073/pnas.0913492107","title":"Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Pyruvate carboxylase; Acetyl-CoA carboxylase; Endocrinology; Internal medicine; Skeletal muscle; Body weight; Obesity; Chemistry; Biology; Biochemistry; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012348,0.0001184932,0.0002989551,0.0001978019,0.0001245853,0.00001220105,0.0005130864,0.0001325165,0.00007756004],"category_scores_gemma":[0.001172618,0.00006314153,0.0001034837,0.000554377,0.000844882,0.000210835,0.00007790524,0.0003109564,0.000005078179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001268648,"about_ca_system_score_gemma":0.0000666202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003962005,"about_ca_topic_score_gemma":1.338989e-7,"domain_scores_codex":[0.9981152,0.00000559368,0.0003257461,0.0002297295,0.001160007,0.0001637338],"domain_scores_gemma":[0.9991001,0.0001767373,0.0003728579,0.00001748364,0.0002663399,0.00006641611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001254323,0.00007349,0.004124244,0.0001067542,0.00003957739,1.876742e-8,0.0001384038,7.620788e-7,0.9740967,0.01863527,0.001124405,0.001534989],"study_design_scores_gemma":[0.0005603418,0.0006472006,0.04505327,0.0001156109,0.00006792886,0.00001710198,0.00002751744,0.00006290642,0.9417091,0.00728136,0.00439211,0.0000655594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892896,0.000201919,6.301352e-7,0.003286738,0.00008726401,0.0003158703,0.00001845687,0.00001267677,0.006786885],"genre_scores_gemma":[0.99656,0.00002841183,0.00202607,0.0002490899,0.0003554394,0.00001048588,3.43014e-7,0.000006893284,0.0007632066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04092903,"threshold_uncertainty_score":0.3113003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04692172967371997,"score_gpt":0.3212618892133593,"score_spread":0.2743401595396393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}