{"id":"W2109069238","doi":"10.1161/circgenetics.111.961417","title":"Effect of <i>PON1</i> Q192R Genetic Polymorphism on Clopidogrel Efficacy and Cardiovascular Events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events Trial and the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events","year":2012,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Paraoxonase enzyme and polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"Johnson and Johnson; St. Jude Medical; Bayer Canada; Boston Scientific Corporation; Sanofi; Eli Lilly and Company","keywords":"Clopidogrel; Internal medicine; Medicine; PON1; Unstable angina; Atrial fibrillation; Cardiology; Hazard ratio; Aspirin; Genotype; Confidence interval; Myocardial infarction; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005762481,0.0004447072,0.0009043737,0.0001888233,0.0001606686,0.00001991569,0.0003757414,0.0002874516,0.000001335198],"category_scores_gemma":[0.0003105408,0.0002808107,0.001401313,0.0004986809,0.000137082,0.00002374884,0.0001006359,0.0001933786,0.000001296459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004387539,"about_ca_system_score_gemma":0.00009070784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006683479,"about_ca_topic_score_gemma":0.00001767322,"domain_scores_codex":[0.9939508,0.003000545,0.0008578963,0.0006272788,0.001050987,0.0005124933],"domain_scores_gemma":[0.9977987,0.0003920082,0.0003103569,0.001294218,0.0001025923,0.0001021195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3750836,0.002001103,0.08915719,0.001310366,0.01594133,0.000008765001,0.005714763,0.3023583,0.003479716,0.0006435325,0.0003043441,0.203997],"study_design_scores_gemma":[0.6572918,0.01783727,0.279496,0.0007700206,0.008559627,0.0001575746,0.0003092778,0.001500154,0.0078402,0.0004143207,0.02402853,0.001795165],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944263,0.04366739,0.002429834,0.00006359997,0.0005611054,0.008954513,0.00003638454,0.000005800681,0.00001837052],"genre_scores_gemma":[0.995564,0.002290672,0.0002085876,0.00004246862,0.001276763,0.0004011634,0.000158952,0.00004962111,0.000007709437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3008581,"threshold_uncertainty_score":0.9999644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527730729958983,"score_gpt":0.2708939301781323,"score_spread":0.2556166228785425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}