{"id":"W2109087897","doi":"10.1136/annrheumdis-2013-203561","title":"ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis","year":2013,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Rheumatology Research Foundation","keywords":"ADAMTS; Cartilage; Medicine; Gene knockdown; Osteoarthritis; Chondrocyte; Matrix metalloproteinase; Pathogenesis; Endochondral ossification; Tumor necrosis factor alpha; Immunohistochemistry; Pathology; Cancer research; Metalloproteinase; Immunology; Internal medicine; Biology; Gene; Anatomy; Thrombospondin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001044308,0.0007003713,0.000742895,0.0007121656,0.0004240715,0.001355298,0.000454682,0.00071933,0.001414696],"category_scores_gemma":[0.001149781,0.0004642135,0.0006744681,0.0002134988,0.0009768743,0.0008341892,0.0008112507,0.00123854,0.0004776189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005167742,"about_ca_system_score_gemma":0.000632286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000328479,"about_ca_topic_score_gemma":0.0002958474,"domain_scores_codex":[0.9985801,0.0005356717,0.0001340015,0.0001271237,0.0004076858,0.0002154211],"domain_scores_gemma":[0.9990894,0.0001614349,0.0002810024,0.00005804949,0.0002168835,0.0001933083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007755373,0.0006561778,0.04205295,0.0008587805,0.0005180757,0.004499551,0.0008597507,0.001614631,0.8611718,0.004799564,0.001765856,0.07344759],"study_design_scores_gemma":[0.001196103,0.007092285,0.2375578,0.0003081822,0.00119067,0.009830909,0.002022521,0.0146183,0.6874424,0.01416246,0.02444533,0.0001330408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957456,0.03013344,0.006930206,0.001727595,0.0004895247,0.00006039047,0.00009100333,0.0001946437,0.002917231],"genre_scores_gemma":[0.9938257,0.003314858,0.001344548,0.00009847814,0.000238344,0.00001981734,0.00005178636,0.00001116525,0.001095313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414696,"threshold_uncertainty_score":0.005522847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175428863808622,"score_gpt":0.2530279352376685,"score_spread":0.2354850488568063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}