{"id":"W2109105309","doi":"10.1053/j.gastro.2009.10.046","title":"Cell-Type Specific Gene Expression Signature in Liver Underlies Response to Interferon Therapy in Chronic Hepatitis C Infection","year":2009,"lang":"en","type":"article","venue":"Gastroenterology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"ISG15; Interferon; Genotype; Phenotype; Biology; Immunology; Interferon-stimulated gene; Ribavirin; Gene expression; Liver biopsy; Gene; Gene expression profiling; Hepatitis C virus; Virology; Virus; Medicine; Biopsy; Internal medicine; Immune system; Genetics; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003452041,0.0002642315,0.0003690681,0.0006365535,0.0000606679,0.00001569845,0.0002276867,0.000350868,0.0006310178],"category_scores_gemma":[0.00003577164,0.000245423,0.00007544412,0.0002038851,0.0000874383,0.0001111469,0.00008031933,0.0005950817,0.0003562364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004500398,"about_ca_system_score_gemma":0.00005310808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002132788,"about_ca_topic_score_gemma":0.0008087352,"domain_scores_codex":[0.9973208,0.001188453,0.0003999953,0.0004363155,0.00003636771,0.0006180835],"domain_scores_gemma":[0.9994233,0.00009525698,0.0000859677,0.0003204561,0.00004641635,0.00002865218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04142555,0.0002414975,0.01919742,0.000003861644,0.0000120564,0.00004327754,0.0008687516,0.0001177947,0.9323707,0.000006843325,0.003002332,0.002709945],"study_design_scores_gemma":[0.003900623,0.01474122,0.454641,0.00008431246,0.000002814208,0.00009709885,0.00004350798,0.000004990491,0.5180513,0.00002511414,0.008253371,0.0001547415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940693,0.003734701,0.0003353712,0.0005942198,0.0007767038,0.0003628379,0.000005729657,0.00005224977,0.00006891837],"genre_scores_gemma":[0.9960899,0.002168796,0.00006172356,0.0009610572,0.00003767963,0.00002329701,0.00004058999,0.00001877536,0.0005982072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4354435,"threshold_uncertainty_score":0.9999998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184360097359333,"score_gpt":0.2390333368659741,"score_spread":0.2271897358923808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}