{"id":"W2109105309","doi":"10.1053/j.gastro.2009.10.046","title":"Cell-Type Specific Gene Expression Signature in Liver Underlies Response to Interferon Therapy in Chronic Hepatitis C Infection","year":2009,"lang":"en","type":"article","venue":"Gastroenterology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"ISG15; Interferon; Genotype; Phenotype; Biology; Immunology; Interferon-stimulated gene; Ribavirin; Gene expression; Liver biopsy; Gene; Gene expression profiling; Hepatitis C virus; Virology; Virus; Medicine; Biopsy; Internal medicine; Immune system; Genetics; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002298073,0.0001504583,0.0003758271,0.0004627873,0.000165946,0.0003623969,0.00008097135,0.000249965,0.0007996481],"category_scores_gemma":[0.0004394804,0.0001373394,0.0001800189,0.0003069282,0.0002453599,0.0001418135,0.0001680003,0.0002902696,0.0001680567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021822,"about_ca_system_score_gemma":0.0001312634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004454961,"about_ca_topic_score_gemma":0.000555822,"domain_scores_codex":[0.9998581,0.00004417189,0.000009875558,0.00002013705,0.00002275303,0.00004487203],"domain_scores_gemma":[0.9997554,0.00007220882,0.00005968206,0.00002115028,0.0000368181,0.00005463067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004342316,0.0000780969,0.07805698,0.0000661031,0.00003965367,0.0002559395,0.0001780585,0.0001668632,0.9101036,0.0001163098,0.00008839164,0.006507654],"study_design_scores_gemma":[0.00004297579,0.0006609755,0.9433568,0.0000103832,0.00006926867,0.0004603577,0.0003606481,0.00138882,0.05293874,0.0002203872,0.0004780728,0.00001262678],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999009,0.0002561175,0.0001971877,0.00002290874,0.000006721393,0.000009405548,0.0001075092,0.000005376997,0.0003857764],"genre_scores_gemma":[0.9992416,0.0001280631,0.0001633042,0.00002572351,0.00001249028,0.00001248201,0.0001265204,0.000004202845,0.0002856489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007996481,"threshold_uncertainty_score":0.002675116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184360097359333,"score_gpt":0.2390333368659741,"score_spread":0.2271897358923808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}