{"id":"W2109122063","doi":"10.2741/singwi","title":"Potential nuclease-based strategies for HIV gene therapy","year":2000,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Genetic enhancement; Nuclease; Gene; Biology; Genome editing; RNA; Virus; Gene delivery; Virology; Lentivirus; Computational biology; Genome; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001889424,0.0002971557,0.0004724218,0.0001496995,0.00006673645,0.00006870969,0.0005100603,0.0002752282,0.000009882158],"category_scores_gemma":[0.00001539653,0.0002628656,0.0002778227,0.0002107236,0.000136013,0.000004166144,0.00003070637,0.0001025005,0.000002785365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002624818,"about_ca_system_score_gemma":0.0003938862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002766653,"about_ca_topic_score_gemma":0.000001318379,"domain_scores_codex":[0.9986084,0.00004230041,0.0002828968,0.0005739201,0.0001245157,0.0003680387],"domain_scores_gemma":[0.9994504,0.000007025676,0.00007585785,0.0003743577,0.00002115392,0.00007117119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003272004,0.00005325577,0.000007445896,0.0007704408,0.00002779255,0.000005241961,0.00001020248,0.001102978,0.001466495,0.000006714976,0.008262339,0.9882544],"study_design_scores_gemma":[0.0003032969,0.0001025368,0.000004087113,0.0002716053,0.00003035322,0.000006563599,0.00001944676,0.0007419391,0.0009748552,0.00002737095,0.9971763,0.0003416582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005641723,0.8176429,0.1809607,0.00001127287,0.0006591493,0.0004739334,0.0001026214,0.00001205556,0.00008095065],"genre_scores_gemma":[0.0002404837,0.9794296,0.0195147,0.00006461555,0.0002204874,0.0001037894,0.0002034841,0.00003946453,0.0001833866],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.988914,"threshold_uncertainty_score":0.9999824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479697224660289,"score_gpt":0.3138359734787518,"score_spread":0.2990390012321489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}