{"id":"W2109130443","doi":"10.2967/jnumed.110.084392","title":"ErbB-2 Blockade and Prenyltransferase Inhibition Alter Epidermal Growth Factor and Epidermal Growth Factor Receptor Trafficking and Enhance <sup>111</sup>In-DTPA-hEGF Auger Electron Radiation Therapy","year":2011,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Oxford Cancer Imaging Centre; Engineering and Physical Sciences Research Council; Medical Research Council; National Institute for Health and Care Research; Cancer Research UK","keywords":"Clonogenic assay; Epidermal growth factor receptor; Chemistry; Epidermal growth factor; Cytotoxicity; Cell culture; Intracellular; Molecular biology; Cell; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009391832,0.0002865272,0.0002807867,0.00008039522,0.00008119852,0.0002400489,0.0001865236,0.0002465571,0.001173563],"category_scores_gemma":[0.00008664486,0.00008986039,0.0001238755,0.00008235592,0.0001996981,0.0002085209,0.0001260852,0.0003248141,0.0002130218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552299,"about_ca_system_score_gemma":0.0001533929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004801011,"about_ca_topic_score_gemma":0.001022776,"domain_scores_codex":[0.9999194,0.00001309219,0.000005434007,0.000009691341,0.00001982097,0.00003248498],"domain_scores_gemma":[0.9999512,0.00001205175,0.00001757591,0.000004739319,0.000003607544,0.00001086529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003822402,0.0001119,0.0002060709,0.00002667439,0.000007807652,0.00003860373,0.00001306947,0.00009760724,0.9976389,0.00007162119,0.00002781419,0.001377597],"study_design_scores_gemma":[0.00004271307,0.001193592,0.00320345,0.000002766343,0.00001892042,0.0002750252,0.00002150339,0.0004315398,0.9933702,0.00002112838,0.001416503,0.000002590405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976022,0.0008051833,0.0005183826,0.00003087763,0.000008748645,0.00001735888,0.00004815327,0.00002362256,0.0009454289],"genre_scores_gemma":[0.997941,0.0003962909,0.0006193215,0.00002024163,0.000003337037,0.00001729353,0.00005824346,0.000007086046,0.0009371783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173563,"threshold_uncertainty_score":0.00392592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787415379008988,"score_gpt":0.29177212261368,"score_spread":0.2638979688235901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}