{"id":"W2109130443","doi":"10.2967/jnumed.110.084392","title":"ErbB-2 Blockade and Prenyltransferase Inhibition Alter Epidermal Growth Factor and Epidermal Growth Factor Receptor Trafficking and Enhance <sup>111</sup>In-DTPA-hEGF Auger Electron Radiation Therapy","year":2011,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Oxford Cancer Imaging Centre; Engineering and Physical Sciences Research Council; Medical Research Council; National Institute for Health and Care Research; Cancer Research UK","keywords":"Clonogenic assay; Epidermal growth factor receptor; Chemistry; Epidermal growth factor; Cytotoxicity; Cell culture; Intracellular; Molecular biology; Cell; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003384388,0.0002596231,0.0005520652,0.0001757796,0.0001031115,0.00001799442,0.00006529363,0.0001600182,0.0003998562],"category_scores_gemma":[0.0001855462,0.0001981932,0.00006623941,0.0001684056,0.0002597628,0.0003289256,0.0000126495,0.000678353,0.000002324918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000694645,"about_ca_system_score_gemma":0.00004427936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001568344,"about_ca_topic_score_gemma":6.967624e-7,"domain_scores_codex":[0.9982821,0.00009672567,0.0006843892,0.0002994222,0.0003117835,0.0003255459],"domain_scores_gemma":[0.9989011,0.0001936034,0.0002271652,0.0001138377,0.0001302018,0.0004341092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002171078,0.0004296916,0.0100927,0.0003656081,0.0001731387,0.0001075195,0.009521578,0.000001806804,0.9587016,0.0001652569,0.0009713552,0.0172987],"study_design_scores_gemma":[0.01961003,0.004583573,0.2760515,0.001570613,0.0004846275,0.002796869,0.001079884,0.001400197,0.6850402,0.0005224186,0.006072484,0.0007876359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879115,0.002474584,0.00009243067,0.008966215,0.00005016058,0.0003143142,0.000008969205,0.00002434342,0.000157513],"genre_scores_gemma":[0.9902398,0.007273682,0.0003923545,0.001168649,0.0008534028,0.00000402111,0.000007727483,0.00003809765,0.00002228335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2736614,"threshold_uncertainty_score":0.8082083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787415379008988,"score_gpt":0.29177212261368,"score_spread":0.2638979688235901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}