{"id":"W2109142098","doi":"10.7554/elife.01998","title":"Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6","year":2014,"lang":"en","type":"article","venue":"eLife","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; American Heart Association","keywords":"Wnt signaling pathway; Phosphorylation; GSK-3; Signal transduction; LRP6; Cell biology; Glycogen synthase; Serine; Phosphorylation cascade; Biochemistry; Kinase; Biology; Chemistry; Protein phosphorylation; Protein kinase A","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510904,0.000077561,0.00006962329,0.000008230609,0.00006251174,0.00001258229,0.00005640545,0.00006920558,0.0000566396],"category_scores_gemma":[0.00002946252,0.00005748797,0.00002422236,0.0000316,0.00006795561,0.000003320708,0.000033238,0.00003997791,0.000002420087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006813351,"about_ca_system_score_gemma":0.00001571564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001398375,"about_ca_topic_score_gemma":0.000002511867,"domain_scores_codex":[0.999488,0.00003356481,0.0001272317,0.000145341,0.0001144617,0.00009140862],"domain_scores_gemma":[0.9997501,0.000009669548,0.00007378795,0.00008865013,0.0000500206,0.00002780962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004239536,0.000005353436,0.003103122,0.000008541195,0.00001507517,4.54829e-8,0.00006831367,0.000003144358,0.920042,0.00001737336,0.06952705,0.00716755],"study_design_scores_gemma":[0.0002587627,0.0000764111,0.001672946,0.000009721006,0.00000819759,0.000002478416,0.0000274081,0.00005205352,0.9603419,0.00002598154,0.03743534,0.00008883407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981557,0.0009534771,0.0002801731,0.000214688,0.0001015383,0.00006504756,0.00001707342,0.000004797461,0.0002075392],"genre_scores_gemma":[0.998439,0.0001324279,0.000202967,0.0002678681,0.000118022,0.000009362321,0.0002091829,0.000008188541,0.000612974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04029983,"threshold_uncertainty_score":0.2344291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005017515931745393,"score_gpt":0.2119795403904607,"score_spread":0.2069620244587153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}