{"id":"W2109143421","doi":"10.1016/s2213-2600(13)70187-5","title":"Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials","year":2013,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Bronchodilator; Asthma; Placebo; COPD; Bronchodilator Agents; Clinical trial; Internal medicine; Pulmonary function testing; Inhalation; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009326402,0.0001218196,0.0004210206,0.00004395139,0.00003781077,0.000005702997,0.00004545962,0.00009036913,0.00001859362],"category_scores_gemma":[0.0005803411,0.00006592029,0.00001494849,0.00007607002,0.0003544844,0.00001071059,0.00005668373,0.0001360438,3.430795e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001998745,"about_ca_system_score_gemma":0.00008021987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007870643,"about_ca_topic_score_gemma":0.0001729759,"domain_scores_codex":[0.9986168,0.0003869753,0.0004631641,0.0002680179,0.0001223491,0.0001426741],"domain_scores_gemma":[0.9993045,0.0002244989,0.0001474779,0.0001783722,0.00004240745,0.0001026959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02744223,0.00008653398,0.9510102,0.00007108309,0.0000493671,0.000005808721,0.0001838255,0.00001385885,0.005724118,0.000007824515,0.0006371228,0.01476806],"study_design_scores_gemma":[0.009819315,0.001216719,0.9863276,0.0001726387,0.00001829106,0.000001443134,0.00006450575,0.00005827331,0.0001401627,0.00002609084,0.002074618,0.00008031786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957108,0.00272761,0.000009494797,0.0008518424,0.000101847,0.0005576556,0.00002246293,0.000003584998,0.00001465892],"genre_scores_gemma":[0.9985632,0.0003996447,0.0000198818,0.0005096018,0.0004180407,0.0000193341,0.00004157252,0.000008967464,0.00001973362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03531746,"threshold_uncertainty_score":0.2688151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04435133549590786,"score_gpt":0.3262270745161338,"score_spread":0.2818757390202259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}