{"id":"W2109145711","doi":"10.1210/jcem.87.8.8764","title":"Androgen Inactivation in Human Lung Fibroblasts: Variations in Levels of 17β-Hydroxysteroid Dehydrogenase Type 2 and 5α-Reductase Activity Compatible with Androgen Inactivation","year":2002,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Medical Research Council","keywords":"Dihydrotestosterone; Testosterone (patch); Internal medicine; Endocrinology; Androgen; Androstenedione; Chemistry; Reductase; Biology; Hormone; Biochemistry; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00120841,0.000197043,0.0007569422,0.0002936154,0.0001210866,0.00000991085,0.0002329019,0.0002373046,0.0002637114],"category_scores_gemma":[0.00064031,0.0001410915,0.00008354877,0.0005736536,0.0003827632,0.0003691285,0.00007079671,0.001396156,0.000002973625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006463978,"about_ca_system_score_gemma":0.00009147418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001147986,"about_ca_topic_score_gemma":0.00007302814,"domain_scores_codex":[0.9969688,0.00115837,0.001172751,0.000201567,0.000178332,0.0003201714],"domain_scores_gemma":[0.996943,0.001524925,0.0009548396,0.0002028759,0.0002401763,0.0001341931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003671624,0.004249826,0.1283793,0.0001070976,0.0009921929,0.00009239978,0.002126769,0.002214915,0.8152133,0.003245795,0.0005942205,0.03911259],"study_design_scores_gemma":[0.01423155,0.0009815594,0.394632,0.0001463731,0.0007611339,0.0006756821,0.0003643227,0.007455153,0.5694114,0.001928622,0.008983511,0.0004287193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968285,0.001092977,0.0001083495,0.001115233,0.0002233953,0.0002991325,0.00001990406,0.000009322359,0.0003031685],"genre_scores_gemma":[0.9981943,0.00117171,0.0001843592,0.0002081622,0.0001749313,0.000007758223,0.000003836757,0.00001540624,0.00003948158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2662527,"threshold_uncertainty_score":0.6065679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.170667456052157,"score_gpt":0.4555238820935599,"score_spread":0.2848564260414029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}