{"id":"W2109179142","doi":"10.1128/mcb.24.20.8813-8822.2004","title":"Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21 <sup>Cip1</sup> Repression","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; Fondazione Italiana per la Ricerca sul Cancro; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Notch signaling pathway; Cell biology; Downregulation and upregulation; Biology; Cyclin A; Retinoblastoma protein; Phosphorylation; Angiogenesis; Cyclin D; Cell cycle; Cyclin A2; Psychological repression; Endothelial stem cell; Cyclin; Signal transduction; Cancer research; Cell; Cyclin-dependent kinase 2; Protein kinase A; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008396264,0.0002682139,0.000158653,0.0003078193,0.0003131662,0.0004268869,0.0001979528,0.0001970439,0.002245684],"category_scores_gemma":[0.0001470204,0.0001113637,0.0001619678,0.0001622307,0.0001788534,0.0002208326,0.0002432071,0.0003670249,0.0005739094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000555033,"about_ca_system_score_gemma":0.0001920613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008526882,"about_ca_topic_score_gemma":0.00123697,"domain_scores_codex":[0.999881,0.00001645489,0.00000913393,0.00001818575,0.00003636577,0.00003880167],"domain_scores_gemma":[0.9998777,0.00002446994,0.00002810146,0.00001822789,0.00001890146,0.00003251288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001975958,0.00004642737,0.0003704445,0.00004644597,0.000004461345,0.0001710716,0.00001736238,0.00008911449,0.9955141,0.0005530229,0.0001335742,0.002856417],"study_design_scores_gemma":[0.00001547252,0.00008954921,0.00926716,0.000003799214,0.000006101763,0.0003304484,0.00001435304,0.00121555,0.9857445,0.0001331084,0.003177514,0.000002397524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876899,0.00303739,0.002956415,0.0001600673,0.00002805738,0.0000385557,0.0004919815,0.0001307521,0.005466961],"genre_scores_gemma":[0.9940102,0.0008323085,0.0007314047,0.00003287038,0.0000127636,0.00003402868,0.0004882232,0.00001277291,0.00384536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002245684,"threshold_uncertainty_score":0.007512569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00512924131541998,"score_gpt":0.2189044565390726,"score_spread":0.2137752152236526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}