{"id":"W2109179142","doi":"10.1128/mcb.24.20.8813-8822.2004","title":"Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21 <sup>Cip1</sup> Repression","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; Fondazione Italiana per la Ricerca sul Cancro; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Notch signaling pathway; Cell biology; Downregulation and upregulation; Biology; Cyclin A; Retinoblastoma protein; Phosphorylation; Angiogenesis; Cyclin D; Cell cycle; Cyclin A2; Psychological repression; Endothelial stem cell; Cyclin; Signal transduction; Cancer research; Cell; Cyclin-dependent kinase 2; Protein kinase A; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571808,0.0001576967,0.0001932347,0.00006689264,0.00005964959,0.00000820808,0.00005497322,0.0003036656,0.000007390237],"category_scores_gemma":[0.00002872371,0.0001462281,0.0000400917,0.00007268064,0.0001346246,0.000008384928,0.00009653195,0.00008848489,0.00000185798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001052719,"about_ca_system_score_gemma":0.0000475239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007694331,"about_ca_topic_score_gemma":0.00001539415,"domain_scores_codex":[0.9989907,0.0001138984,0.0002546059,0.0003847693,0.00005030035,0.0002056931],"domain_scores_gemma":[0.9996499,0.00001209567,0.00009811132,0.0001528727,0.00003111278,0.00005588697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001533376,0.0000797192,0.00595187,0.00001763595,0.00001901581,0.000004612727,0.0001944049,0.0003022247,0.9911876,0.0004555164,0.000001678846,0.001632372],"study_design_scores_gemma":[0.001148689,0.0003603305,0.004667983,0.00002909883,0.00001128236,0.000007891784,0.0001777912,0.00004050239,0.9910788,0.00201475,0.000300475,0.0001624206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972996,0.001406924,0.0006288839,0.0001119868,0.00003480219,0.0001827015,0.0000124044,0.000006703183,0.0003160051],"genre_scores_gemma":[0.9990456,0.0001488475,0.000268003,0.00009855918,0.00004173855,0.00002316463,0.0003471148,0.00001137138,0.00001557107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00174604,"threshold_uncertainty_score":0.596301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00512924131541998,"score_gpt":0.2189044565390726,"score_spread":0.2137752152236526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}