{"id":"W2109205063","doi":"10.1128/aac.47.6.1798-1804.2003","title":"Oral Bioavailability and In Vivo Efficacy of the Helicase-Primase Inhibitor BILS 45 BS against Acyclovir-Resistant Herpes Simplex Virus Type 1","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Herpes simplex virus; Bioavailability; In vivo; Pharmacology; Oral administration; Virology; Chemistry; Biology; Virus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002677359,0.0003689127,0.000442964,0.0002181809,0.0001529672,0.0003406772,0.0002244855,0.0002599866,0.0017572],"category_scores_gemma":[0.0003368356,0.0001852356,0.0001717675,0.0001412084,0.0002373113,0.0003007018,0.0001243344,0.0004482915,0.000441539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003171582,"about_ca_system_score_gemma":0.0002207846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009616993,"about_ca_topic_score_gemma":0.0005124584,"domain_scores_codex":[0.9998283,0.000062529,0.00001056369,0.00002856121,0.00003285726,0.00003701157],"domain_scores_gemma":[0.9998566,0.00005149078,0.00003588768,0.00001136535,0.00001814372,0.00002657909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003649259,0.0002697415,0.000532233,0.00009159287,0.00003950447,0.00006548401,0.00003950847,0.0005992595,0.9812034,0.00006823619,0.0001791435,0.01326256],"study_design_scores_gemma":[0.0002789056,0.01227526,0.005766999,0.00001260607,0.0001052185,0.0003076212,0.00004675463,0.003022113,0.9755149,0.00007087741,0.002582615,0.00001609745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932714,0.003896006,0.001401545,0.00005823657,0.00002058593,0.00003319695,0.0002413609,0.00006764051,0.001009994],"genre_scores_gemma":[0.9962238,0.001583023,0.0007151547,0.00002850314,0.00002749884,0.00002448266,0.00044883,0.00002340753,0.0009252332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0017572,"threshold_uncertainty_score":0.005878448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871954607689574,"score_gpt":0.2797895397074993,"score_spread":0.2610699936306035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}