{"id":"W2109215179","doi":"10.1111/j.1365-2516.2006.01259.x","title":"Cellular and genetic therapies for haemophilia","year":2006,"lang":"en","type":"review","venue":"Haemophilia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Genetic enhancement; Haemophilia; Clinical trial; Vector (molecular biology); Immune system; Transgene; Disease; Haemophilia A; Gene transfer; Viral vector; Immunology; Bioinformatics; Computational biology; Gene; Biology; Genetics; Recombinant DNA; Internal medicine; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002923319,0.0006996857,0.001184157,0.0001787598,0.000193062,0.00008784811,0.0005829106,0.0007001995,0.00003639179],"category_scores_gemma":[0.00004849454,0.000612949,0.0006061659,0.0001726909,0.000273385,0.000003226807,0.0002175756,0.0002585354,0.00003844267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003869473,"about_ca_system_score_gemma":0.0003035993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001132868,"about_ca_topic_score_gemma":0.00005625541,"domain_scores_codex":[0.9972143,0.0002162512,0.0005818037,0.001055782,0.0002639671,0.0006679465],"domain_scores_gemma":[0.9983938,0.00006121865,0.000225314,0.001029165,0.0001217258,0.0001687924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001845997,0.00007147594,0.000005815996,0.005593493,0.0003965365,0.00002751311,0.0000134858,0.00000301736,0.003657174,0.00002488116,0.008699785,0.9813222],"study_design_scores_gemma":[0.0004730641,0.001323319,0.000004930056,0.0005291391,0.000281862,0.00006123493,0.000003699546,0.000008257012,0.002078362,0.0003197002,0.994258,0.0006584473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001835103,0.9952313,0.0002342745,0.00005817761,0.0002131225,0.001899829,0.000314927,0.0000315573,0.0001816644],"genre_scores_gemma":[0.000210562,0.9925634,0.0007498201,0.00009071653,0.001254238,0.0005537125,0.001098293,0.0002237818,0.003255481],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9855582,"threshold_uncertainty_score":0.9996322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04217691388546592,"score_gpt":0.3337576758620027,"score_spread":0.2915807619765368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}