{"id":"W2109215179","doi":"10.1111/j.1365-2516.2006.01259.x","title":"Cellular and genetic therapies for haemophilia","year":2006,"lang":"en","type":"review","venue":"Haemophilia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Genetic enhancement; Haemophilia; Clinical trial; Vector (molecular biology); Immune system; Transgene; Disease; Haemophilia A; Gene transfer; Viral vector; Immunology; Bioinformatics; Computational biology; Gene; Biology; Genetics; Recombinant DNA; Internal medicine; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005005498,0.001074876,0.001061694,0.002318735,0.0004113841,0.0007048643,0.0007908014,0.001244498,0.006218009],"category_scores_gemma":[0.0003525406,0.0002421296,0.0004008626,0.001640385,0.0006033967,0.001056183,0.0006845382,0.002375754,0.005589451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005594845,"about_ca_system_score_gemma":0.0006009481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000844166,"about_ca_topic_score_gemma":0.001769284,"domain_scores_codex":[0.9998091,0.00003179185,0.00001689269,0.00002496344,0.0001007133,0.00001651263],"domain_scores_gemma":[0.9998786,0.00004517593,0.00001693661,0.000008095236,0.00003032338,0.0000208228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006567019,0.0001283453,0.0001060295,0.004419389,0.00004661388,0.0003091162,0.00005772356,0.0002864447,0.004262285,0.005197281,0.04921541,0.9359057],"study_design_scores_gemma":[0.00002829695,0.00008667336,0.0003814934,0.0007492147,0.0000264046,0.001461764,0.00002430632,0.00003795506,0.0005484624,0.001741734,0.9949043,0.000009288585],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001480299,0.9963237,0.0002367373,0.0002779714,0.0003486307,0.00001246846,0.00001462193,0.00001311634,0.002624691],"genre_scores_gemma":[0.0007976164,0.9950977,0.000413355,0.000289237,0.0002381975,0.00002041579,0.00004329006,0.000003004046,0.003097128],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006218009,"threshold_uncertainty_score":0.02080137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04217691388546592,"score_gpt":0.3337576758620027,"score_spread":0.2915807619765368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}