{"id":"W2109221130","doi":"10.1152/ajpgi.90585.2008","title":"A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Farnesoid X receptor; Internal medicine; Endocrinology; Agonist; Nuclear receptor; Cholesterol; Dyslipidemia; Chemistry; Obeticholic acid; Fenofibrate; Receptor; Biology; Medicine; Biochemistry; Diabetes mellitus; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002802227,0.0006365376,0.0008350484,0.0007354092,0.0002305368,0.0004513392,0.0003691294,0.0004372954,0.001644431],"category_scores_gemma":[0.0001721438,0.0002790701,0.0004922501,0.0004851949,0.0003008377,0.0003789535,0.0002596413,0.001446065,0.0004769687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407204,"about_ca_system_score_gemma":0.0004217236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007647459,"about_ca_topic_score_gemma":0.001425464,"domain_scores_codex":[0.9997552,0.00004453367,0.0000376219,0.00003780432,0.00006794059,0.00005683507],"domain_scores_gemma":[0.9997776,0.00001728165,0.00005954279,0.00002470927,0.00002404702,0.00009676821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003296158,0.001132054,0.0003308128,0.0002104473,0.00005474158,0.0001346711,0.00004338372,0.00008750774,0.9857452,0.000162621,0.0004511131,0.008351242],"study_design_scores_gemma":[0.0006259962,0.008646113,0.00932757,0.00003979408,0.0001937827,0.0004410196,0.00008287901,0.0008247649,0.9741685,0.0001671185,0.005455443,0.00002695287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861224,0.005664236,0.003212989,0.0005230555,0.0002340469,0.0001001676,0.0008554768,0.0006272292,0.002660416],"genre_scores_gemma":[0.9796287,0.006778658,0.004722458,0.0003467768,0.0001041178,0.0002255634,0.001794347,0.0000878641,0.006311464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644431,"threshold_uncertainty_score":0.005501151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009745863796113132,"score_gpt":0.2318695354180992,"score_spread":0.222123671621986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}