{"id":"W2109240928","doi":"10.1177/2040206614566580","title":"Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor","year":2015,"lang":"en","type":"article","venue":"Antiviral chemistry & chemotherapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Lignan; Reverse transcriptase; Reverse-transcriptase inhibitor; Nucleoside Reverse Transcriptase Inhibitor; Enzyme; Human immunodeficiency virus (HIV); Biology; Nucleoside; Mechanism of action; In vitro; EC50; Drug; Virology; Pharmacology; Chemistry; Biochemistry; Stereochemistry; Viral disease; Antiretroviral therapy; Sida; Viral load; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009992,0.000240505,0.0001645597,0.0002463975,0.00009512765,0.000258304,0.000179288,0.0002028817,0.001635673],"category_scores_gemma":[0.00006601745,0.00007059886,0.0001699249,0.0002036529,0.000124667,0.0001690537,0.0001224445,0.0002648353,0.0003837113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002592991,"about_ca_system_score_gemma":0.0002944514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004280305,"about_ca_topic_score_gemma":0.001157419,"domain_scores_codex":[0.9999698,0.000004182979,0.000001529941,0.000006305331,0.00001026009,0.000007865242],"domain_scores_gemma":[0.9999648,0.000004622841,0.000006011614,0.000003485845,0.000009334513,0.00001180158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007670007,0.00006945053,0.0002723601,0.00006763435,0.000006159184,0.0001404976,0.00001435036,0.0003503248,0.9927689,0.0003304981,0.00006338758,0.005839794],"study_design_scores_gemma":[0.00005449051,0.001254905,0.004961151,0.00002614588,0.00003455324,0.0006014696,0.00003913312,0.001824683,0.9779489,0.0003382946,0.01290363,0.00001277974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753959,0.004857182,0.01047693,0.000298522,0.00003953072,0.0001448136,0.0007252,0.00006436068,0.007997573],"genre_scores_gemma":[0.9796284,0.002814967,0.01006168,0.0001475383,0.0000183669,0.00002865026,0.001192455,0.00001089731,0.006096978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635673,"threshold_uncertainty_score":0.005471885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00906468489302717,"score_gpt":0.2314458601651324,"score_spread":0.2223811752721052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}