{"id":"W2109270957","doi":"10.2337/db09-1293","title":"Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":358,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Fondation pour la Recherche Médicale; University of Alberta; Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"Ceramide; Insulin resistance; Internal medicine; Endocrinology; Sphingolipid; Insulin receptor; Protein kinase B; Insulin; Diet-induced obese; Glycogen synthase; Biology; Skeletal muscle; Biochemistry; Signal transduction; Medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002567671,0.0001073527,0.000154587,0.0000395004,0.00006327204,0.00002031831,0.00006745382,0.0001465153,0.00001550178],"category_scores_gemma":[0.0004432359,0.0001057056,0.0000425196,0.00004683881,0.00009387919,0.000009415066,0.00003825497,0.00008962265,0.000002862394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003496605,"about_ca_system_score_gemma":0.00002741532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009148664,"about_ca_topic_score_gemma":0.00003558402,"domain_scores_codex":[0.9993019,0.00004749114,0.0001724161,0.0002212423,0.00007925859,0.0001776654],"domain_scores_gemma":[0.9995487,0.00005927919,0.00009875291,0.0001773386,0.0000620344,0.00005390266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004835288,0.0000240592,0.008100305,0.00007478287,0.00002281738,4.520226e-7,0.00006428777,7.930694e-7,0.9906511,0.00008251956,0.00005768733,0.0008728713],"study_design_scores_gemma":[0.0002417329,0.00003593731,0.02423763,0.00006060979,0.00002928772,5.109715e-7,0.00004368441,0.00001205193,0.9734774,0.0001239828,0.001615822,0.000121389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983119,0.001186309,0.00003432932,0.00008538307,0.0001212819,0.00008442369,0.0000374315,0.00001106354,0.0001278514],"genre_scores_gemma":[0.9984319,0.0003284248,0.0008475276,0.00008267655,0.0001896585,0.00002392052,0.00003268696,0.00001284992,0.00005037663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01717371,"threshold_uncertainty_score":0.4310549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008872024028774645,"score_gpt":0.2323554621705076,"score_spread":0.223483438141733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}