{"id":"W2109280317","doi":"10.1023/a:1026192228471","title":"Optimization and control of perfusion cultures using a viable cell probe and cell specific perfusion rates","year":2003,"lang":"en","type":"article","venue":"Cytotechnology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Inimex Pharmaceuticals (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioreactor; Chinese hamster ovary cell; Perfusion; Cell culture; Cell; Biology; Plasminogen activator; Chemistry; Chromatography; Biochemistry; Internal medicine; Medicine; Endocrinology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007035715,0.0001329,0.0001505467,0.00006283574,0.000136945,0.00001565026,0.00005813281,0.0002923157,0.00003756477],"category_scores_gemma":[0.00003120866,0.0001154725,0.00003346496,0.00007878452,0.0001444763,0.00000541481,0.0000727503,0.0000807852,7.220417e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006752336,"about_ca_system_score_gemma":0.00002510434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001118442,"about_ca_topic_score_gemma":0.000001184781,"domain_scores_codex":[0.9992816,0.00005484244,0.0001567253,0.0003020007,0.00004580908,0.0001590445],"domain_scores_gemma":[0.9995832,0.000007183964,0.000102878,0.0001889669,0.00007134467,0.00004642787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004541999,0.00007356516,0.001606894,0.0000399194,0.000003885152,9.645354e-7,0.00002421785,0.003208628,0.9943566,0.0000794111,0.0003987141,0.0001618205],"study_design_scores_gemma":[0.001033182,0.0004016425,0.00003855561,0.00001985443,0.00001903141,0.00002849074,0.000147365,0.002889139,0.9889098,0.0001930421,0.006173435,0.0001464606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458784,0.01228946,0.04118076,0.00002472237,0.00007286471,0.000228821,0.000008536374,0.00001791378,0.0002985568],"genre_scores_gemma":[0.9925924,0.00288635,0.004280573,0.00006275188,0.0000265428,0.00001002916,0.00001290552,0.00001540517,0.0001130554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04671403,"threshold_uncertainty_score":0.4708832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005705288351567999,"score_gpt":0.2249883580971525,"score_spread":0.2192830697455845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}