{"id":"W2109280317","doi":"10.1023/a:1026192228471","title":"Optimization and control of perfusion cultures using a viable cell probe and cell specific perfusion rates","year":2003,"lang":"en","type":"article","venue":"Cytotechnology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Inimex Pharmaceuticals (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioreactor; Chinese hamster ovary cell; Perfusion; Cell culture; Cell; Biology; Plasminogen activator; Chemistry; Chromatography; Biochemistry; Internal medicine; Medicine; Endocrinology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002587229,0.001940899,0.00142508,0.0008562123,0.000862284,0.001639064,0.001372281,0.001214537,0.001557685],"category_scores_gemma":[0.003508351,0.0007221888,0.0005968272,0.0009131291,0.0008264486,0.001221315,0.0008986974,0.001529746,0.001090736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001296079,"about_ca_system_score_gemma":0.001088074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001826961,"about_ca_topic_score_gemma":0.00405869,"domain_scores_codex":[0.9975701,0.0004471365,0.0004459167,0.0006504774,0.0006357216,0.000250533],"domain_scores_gemma":[0.9963982,0.001883164,0.0004524242,0.0004182238,0.0006816805,0.000166261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006740968,0.00004492624,0.0001772961,0.00004965049,0.000004311433,0.00002296607,0.00006727924,0.0001772936,0.996879,0.000131406,0.00006884438,0.002309775],"study_design_scores_gemma":[0.000008673576,0.00006596605,0.000498543,0.000004525126,0.00001402802,0.00002190928,0.0000183298,0.0007849843,0.9974648,0.00002403023,0.001084789,0.000009420458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6554893,0.002678056,0.3305796,0.0006160039,0.0004453971,0.002559831,0.001176675,0.002495331,0.003959837],"genre_scores_gemma":[0.5911133,0.003128296,0.3855749,0.000378067,0.0001635694,0.006977132,0.001965703,0.001769224,0.00892978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002587229,"threshold_uncertainty_score":0.01368272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005705288351567999,"score_gpt":0.2249883580971525,"score_spread":0.2192830697455845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}